Physical properties of the bacterial outer membrane

J Sun, ST Rutherford, TJ Silhavy… - Nature Reviews …, 2022 - nature.com
It has long been appreciated that the Gram-negative outer membrane acts as a permeability
barrier, but recent studies have uncovered a more expansive and versatile role for the outer …

How to enter a bacterium: bacterial porins and the permeation of antibiotics

JD Prajapati, U Kleinekathöfer… - Chemical …, 2021 - ACS Publications
Despite tremendous successes in the field of antibiotic discovery seen in the previous
century, infectious diseases have remained a leading cause of death. More specifically …

Lipopolysaccharide O-antigens—bacterial glycans made to measure

C Whitfield, DM Williams, SD Kelly - Journal of Biological Chemistry, 2020 - ASBMB
Lipopolysaccharides are critical components of bacterial outer membranes. The more
conserved lipid A part of the lipopolysaccharide molecule is a major element in the …

Role of the lipid bilayer in outer membrane protein folding in Gram-negative bacteria

JE Horne, DJ Brockwell, SE Radford - Journal of Biological Chemistry, 2020 - ASBMB
β-Barrel outer membrane proteins (OMPs) represent the major proteinaceous component of
the outer membrane (OM) of Gram-negative bacteria. These proteins perform key roles in …

[HTML][HTML] Lipopolysaccharides at solid and liquid interfaces: models for biophysical studies of the gram-negative bacterial outer membrane

N Paracini, E Schneck, A Imberty, S Micciulla - Advances in Colloid and …, 2022 - Elsevier
Lipopolysaccharides (LPSs) are a constitutive element of the cell envelope of Gram-
negative bacteria, representing the main lipid in the external leaflet of their outer membrane …

The controversial role of LPS in platelet activation in vitro

L Galgano, GF Guidetti, M Torti, I Canobbio - International Journal of …, 2022 - mdpi.com
Circulating platelets are responsible for hemostasis and thrombosis but are also primary
sensors of pathogens and are involved in innate immunity, inflammation, and sepsis. Sepsis …

Outer Membrane Proteins and Efflux Pumps Mediated Multi-Drug Resistance in Salmonella: Rising Threat to Antimicrobial Therapy

SD Akshay, VK Deekshit, J Mohan Raj… - ACS Infectious …, 2023 - ACS Publications
Despite colossal achievements in antibiotic therapy in recent decades, drug-resistant
pathogens have remained a leading cause of death and economic loss globally. One such …

Restoring and enhancing the potency of existing antibiotics against drug-resistant gram-negative bacteria through the development of potent small-molecule …

B Yu, M Roy Choudhury, X Yang, SL Benoit… - ACS Infectious …, 2022 - ACS Publications
The rapid and persistent emergence of drug-resistant bacteria poses a looming public
health crisis. The possible task of developing new sets of antibiotics to replenish the existing …

MALDI‐TOF mass spectroscopy applications in clinical microbiology

M Alizadeh, L Yousefi, F Pakdel… - Advances in …, 2021 - Wiley Online Library
There is a range of proteomics methods to spot and analyze bacterial protein contents such
as liquid chromatography‐mass spectrometry (LC‐MS), two‐dimensional gel …

Genomic Diversity, Antimicrobial Resistance, and Virulence Gene Profiles of Salmonella Serovar Kentucky Isolated from Humans, Food, and Animal Ceca Content …

H Tate, CH Hsu, JC Chen, J Han, SL Foley… - Foodborne …, 2022 - liebertpub.com
Salmonella serovar Kentucky is frequently isolated from chickens and dairy cattle, but
recovery from humans is comparatively low based on the US National Antimicrobial …