Uveal melanoma (UM), a rare cancer of the eye, is distinct from cutaneous melanoma by its
etiology, the mutation frequency and profile, and its clinical behavior including resistance to …

Heterotrimeric G proteins are key players in transmembrane signaling by coupling a huge
variety of receptors to channel proteins, enzymes, and other effector molecules. Multiple …

During vertebrate craniofacial development, neural crest cells (NCCs) contribute much of the
cartilage, bone and connective tissue that make up the developing head. Although the initial …

Head development in vertebrates involves a complex series of molecular and
morphogenetic events that generate a coordinated pattern of cartilages, bones and nerves …

Gq family members of heterotrimeric G protein activate β isoforms of phospholipase C that
hydrolyzes phosphatidylinositol phosphate to diacylglycerol and inositol trisphosphate …

Clefts of the palate are common birth defects requiring extensive treatment. They appear to
be caused by multiple genetic and environmental factors during palatogenesis. This may …

The focus of developmental biologists has expanded from the analysis of gene expression
to include the analysis of cell signalling. Heterotrimeric G proteins (G proteins) mediate …

A new class of dominant dark skin (Dsk) mutations discovered in a screen of∼ 30,000 mice
is caused by increased dermal melanin. We identified three of four such mutations as …

Members of the Twist-family of bHLH proteins play a pivotal role in a number of essential
developmental programs. Twist-family bHLH proteins function by dimerizing with other …

Uveal melanoma is the most common intraocular malignancy although it is a rare subset of
all melanomas. Uveal melanoma has distinct biology relative to cutaneous melanoma, with …