In pharmacogenomic studies, the use of human liver microsomes as a model system to
evaluate the impact of complex genomic traits (ie, linkage-disequilibrium patterns, coding …

Many chemical and biological experiments involve multiple treatment factors and often it is
convenient to fit a non-linear model in these factors. This non-linear model can be …

Biochemical mechanism studies often assume statistical models derived from Michaelis–
Menten kinetics, which are used to approximate initial reaction rate data given the …

Accelerated degradation tests are used to provide accurate estimation of lifetime
characteristics of highly reliable products within a relatively short testing time. Data from …

Implementing optimal design can provide the most accurate statistical inference with
minimal cost. However, optimal designs for high-dimensional models or complicated …

비선형 혼합효과 모형은 다양한 분야에서 반복 측정 자료를 분석할 때 주로 사용된다. 비선형
혼합효과 모형은 개체 내 변동 (intra-individual variation) 에 대해 고려하는 제 1 단계 …

A nonlinear mixed effects model is mainly used to analyze repeated measurement data in
various fields. A nonlinear mixed effects model consists of two stages: the first-stage …

Optimal design is useful in improving the efficiencies of experiments with respect to a
specified optimality criterion, which is often related to one or more statistical models …

El objetivo de esta Tesis Doctoral es construir diseños óptimos para estimación de
parámetros y discriminación entre dos modelos de efectos mixtos no lineales anidados, con …