Metformin: update on mechanisms of action and repurposing potential

M Foretz, B Guigas, B Viollet - Nature Reviews Endocrinology, 2023 - nature.com
Currently, metformin is the first-line medication to treat type 2 diabetes mellitus (T2DM) in
most guidelines and is used daily by> 200 million patients. Surprisingly, the mechanisms …

[HTML][HTML] Metformin: Is it a drug for all reasons and diseases?

CR Triggle, I Mohammed, K Bshesh, I Marei, K Ye… - Metabolism, 2022 - Elsevier
Metformin was first used to treat type 2 diabetes in the late 1950s and in 2022 remains the
first-choice drug used daily by approximately 150 million people. An accumulation of …

Occurrence and removal of pharmaceuticals in wastewater treatment plants

OFS Khasawneh, P Palaniandy - Process Safety and Environmental …, 2021 - Elsevier
Pharmaceutical compounds, such as antibiotics, nonsteroidal anti-inflammatory drugs
(NSAIDs), anticonvulsants, β-blocker, etc. have emerged as new classes of water pollutants …

Metformin contamination in global waters: Biotic and abiotic transformation, byproduct generation and toxicity, and evaluation as a pharmaceutical indicator

Y He, Y Zhang, F Ju - Environmental Science & Technology, 2022 - ACS Publications
Metformin is the first-line antidiabetic drug and one of the most prescribed medications
worldwide. Because of its ubiquitous occurrence in global waters and demonstrated …

Metformin: A review of potential mechanism and therapeutic utility beyond diabetes

S Dutta, RB Shah, S Singhal, SB Dutta… - Drug Design …, 2023 - Taylor & Francis
Metformin has been designated as one of the most crucial first-line therapeutic agents in the
management of type 2 diabetes mellitus. Primarily being an antihyperglycemic agent …

Metformin as an emerging concern in wastewater: Occurrence, analysis and treatment methods

A Balakrishnan, M Sillanpää, MM Jacob… - Environmental Research, 2022 - Elsevier
Metformin is a wonder drug used as an anti-hypoglycemic medication; it is also used as a
cancer suppression medicament. Metformin is a first line of drug choice used by doctors for …

Metformin environmental exposure: A systematic review

EP Ambrosio-Albuquerque, LF Cusioli… - Environmental …, 2021 - Elsevier
This review discussed the occurrence, ecological impacts, and effects of metformin, a drug
used for type 2 diabetes among other diseases. It is one of the most commonly found …

Antidiabetic drug metformin disrupts the embryogenesis in zebrafish through an oxidative stress mechanism

GA Elizalde-Velázquez, LM Gómez-Oliván… - Chemosphere, 2021 - Elsevier
In recent years, the consumption of metformin has increased not only due to the higher
prevalence of type 2 diabetes, but also due to their usage for other indications such as …

Occurrence and spatiotemporal dynamics of pharmaceuticals in a temperate-region wastewater effluent-dominated stream: variable inputs and differential attenuation …

H Zhi, DW Kolpin, RD Klaper… - … science & technology, 2020 - ACS Publications
Effluent-dominated streams are becoming increasingly common in temperate regions and
generate complex pharmaceutical mixture exposure conditions that may impact aquatic …

Occurrence, toxic effects and removal of metformin in the aquatic environments in the world: Recent trends and perspectives

GA Elizalde-Velázquez, LM Gómez-Oliván - Science of The Total …, 2020 - Elsevier
Metformin (MET) is the most common drug used to treat type 2 diabetes, but also it is used
as an anticancer agent and as a treatment for polycystic ovary syndrome. This drug is not …