Mobile genetic element flexibility as an underlying principle to bacterial evolution
AJ Weisberg, JH Chang - Annual Review of Microbiology, 2023 - annualreviews.org
Mobile genetic elements are key to the evolution of bacteria and traits that affect host and
ecosystem health. Here, we use a framework of a hierarchical and modular system that …
ecosystem health. Here, we use a framework of a hierarchical and modular system that …
Ecological and evolutionary solutions to the plasmid paradox
MA Brockhurst, E Harrison - Trends in microbiology, 2022 - cell.com
The'plasmid paradox'arises because, although plasmids are common features of bacterial
genomes, theoretically they should not exist: rates of conjugation were believed insufficient …
genomes, theoretically they should not exist: rates of conjugation were believed insufficient …
Horizontal gene transfer among host-associated microbes
Horizontal gene transfer is an important evolutionary force, facilitating bacterial diversity. It is
thought to be pervasive in host-associated microbiomes, where bacterial densities are high …
thought to be pervasive in host-associated microbiomes, where bacterial densities are high …
Selfish, promiscuous and sometimes useful: how mobile genetic elements drive horizontal gene transfer in microbial populations
M Haudiquet, JM de Sousa… - … Transactions of the …, 2022 - royalsocietypublishing.org
Horizontal gene transfer (HGT) drives microbial adaptation but is often under the control of
mobile genetic elements (MGEs) whose interests are not necessarily aligned with those of …
mobile genetic elements (MGEs) whose interests are not necessarily aligned with those of …
[HTML][HTML] How do interactions between mobile genetic elements affect horizontal gene transfer?
T Horne, VT Orr, JPJ Hall - Current Opinion in Microbiology, 2023 - Elsevier
Highlights•Collaboration and conflict between MGEs can promote and inhibit HGT•Many
genome defences are MGE-encoded, serving MGE interests and changing frequently•The …
genome defences are MGE-encoded, serving MGE interests and changing frequently•The …
Host-specific plasmid evolution explains the variable spread of clinical antibiotic-resistance plasmids
F Benz, AR Hall - Proceedings of the National Academy of …, 2023 - National Acad Sciences
Antibiotic resistance encoded on plasmids is a pressing global health problem. Predicting
which plasmids spread in the long term remains very challenging, even though some key …
which plasmids spread in the long term remains very challenging, even though some key …
Regulatory fine-tuning of mcr-1 increases bacterial fitness and stabilises antibiotic resistance in agricultural settings
Antibiotic resistance tends to carry fitness costs, making it difficult to understand how
resistance can be maintained in the absence of continual antibiotic exposure. Here we …
resistance can be maintained in the absence of continual antibiotic exposure. Here we …
Within-patient evolution of plasmid-mediated antimicrobial resistance
J DelaFuente, L Toribio-Celestino… - Nature ecology & …, 2022 - nature.com
Antimicrobial resistance (AMR) in bacteria is a major threat to public health; one of the key
elements in the spread and evolution of AMR in clinical pathogens is the transfer of …
elements in the spread and evolution of AMR in clinical pathogens is the transfer of …
Cooperative antibiotic resistance facilitates horizontal gene transfer
The rise of β-lactam resistance among pathogenic bacteria, due to the horizontal transfer of
plasmid-encoded β-lactamases, is a current global health crisis. Importantly, β-lactam …
plasmid-encoded β-lactamases, is a current global health crisis. Importantly, β-lactam …
Mathematical models of plasmid population dynamics
JCR Hernández-Beltrán, A San Millán… - Frontiers in …, 2021 - frontiersin.org
With plasmid-mediated antibiotic resistance thriving and threatening to become a serious
public health problem, it is paramount to increase our understanding of the forces that …
public health problem, it is paramount to increase our understanding of the forces that …