TEER measurement techniques for in vitro barrier model systems
Transepithelial/transendothelial electrical resistance (TEER) is a widely accepted
quantitative technique to measure the integrity of tight junction dynamics in cell culture …
quantitative technique to measure the integrity of tight junction dynamics in cell culture …
Impedance-based cell monitoring: barrier properties and beyond
K Benson, S Cramer, HJ Galla - Fluids and Barriers of the CNS, 2013 - Springer
In multicellular organisms epithelial and endothelial cells form selective permeable
interfaces between tissue compartments of different chemical compositions. Tight junctions …
interfaces between tissue compartments of different chemical compositions. Tight junctions …
Blood‐brain barrier‐specific properties of a human adult brain endothelial cell line
BB Weksler, EA Subileau, N Perriere… - The FASEB …, 2005 - Wiley Online Library
Establishment of a human model of the blood‐brain barrier has proven to be a difficult goal.
To accomplish this, normal human brain endothelial cells were transduced by lentiviral …
To accomplish this, normal human brain endothelial cells were transduced by lentiviral …
Dysregulation of glutathione homeostasis in neurodegenerative diseases
WM Johnson, AL Wilson-Delfosse, JJ Mieyal - Nutrients, 2012 - mdpi.com
Dysregulation of glutathione homeostasis and alterations in glutathione-dependent enzyme
activities are increasingly implicated in the induction and progression of neurodegenerative …
activities are increasingly implicated in the induction and progression of neurodegenerative …
Modelling of the blood–brain barrier in drug discovery and development
R Cecchelli, V Berezowski, S Lundquist… - Nature reviews Drug …, 2007 - nature.com
The market for neuropharmaceuticals is potentially one of the largest sectors of the global
pharmaceutical market owing to the increase in average life expectancy and the fact that …
pharmaceutical market owing to the increase in average life expectancy and the fact that …
Permeability studies on in vitro blood–brain barrier models: physiology, pathology, and pharmacology
MA Deli, CS Ábrahám, Y Kataoka, M Niwa - Cellular and molecular …, 2005 - Springer
The specifically regulated restrictive permeability barrier to cells and molecules is the most
important feature of the blood–brain barrier (BBB). The aim of this review was to summarize …
important feature of the blood–brain barrier (BBB). The aim of this review was to summarize …
Endothelium in vitro: a review of human vascular endothelial cell lines for blood vessel-related research
D Bouïs, GAP Hospers, C Meijer, G Molema… - Angiogenesis, 2001 - Springer
Endothelial cells (EC) are currently used as in vitro model systems for various physiological
and pathological processes, especially in angiogenesis research. Primary EC have a limited …
and pathological processes, especially in angiogenesis research. Primary EC have a limited …
Pro-inflammatory TNFα and IL-1β differentially regulate the inflammatory phenotype of brain microvascular endothelial cells
SJ O'Carroll, DT Kho, R Wiltshire, V Nelson… - Journal of …, 2015 - Springer
Background The vasculature of the brain is composed of endothelial cells, pericytes and
astrocytic processes. The endothelial cells are the critical interface between the blood and …
astrocytic processes. The endothelial cells are the critical interface between the blood and …
A novel human induced pluripotent stem cell blood-brain barrier model: Applicability to study antibody-triggered receptor-mediated transcytosis
M Ribecco-Lutkiewicz, C Sodja, J Haukenfrers… - Scientific reports, 2018 - nature.com
We have developed a renewable, scalable and transgene free human blood-brain barrier
model, composed of brain endothelial cells (BECs), generated from human amniotic fluid …
model, composed of brain endothelial cells (BECs), generated from human amniotic fluid …
In vitro model for evaluating drug transport across the blood–brain barrier
R Cecchelli, B Dehouck, L Descamps, L Fenart… - Advanced drug delivery …, 1999 - Elsevier
The passage of substances across the blood–brain barrier (BBB) is regulated in the cerebral
capillaries, which possess certain distinct different morphological and enzymatic properties …
capillaries, which possess certain distinct different morphological and enzymatic properties …