Transepithelial/transendothelial electrical resistance (TEER) is a widely accepted
quantitative technique to measure the integrity of tight junction dynamics in cell culture …

In multicellular organisms epithelial and endothelial cells form selective permeable
interfaces between tissue compartments of different chemical compositions. Tight junctions …

Establishment of a human model of the blood‐brain barrier has proven to be a difficult goal.
To accomplish this, normal human brain endothelial cells were transduced by lentiviral …

Dysregulation of glutathione homeostasis and alterations in glutathione-dependent enzyme
activities are increasingly implicated in the induction and progression of neurodegenerative …

The market for neuropharmaceuticals is potentially one of the largest sectors of the global
pharmaceutical market owing to the increase in average life expectancy and the fact that …

The specifically regulated restrictive permeability barrier to cells and molecules is the most
important feature of the blood–brain barrier (BBB). The aim of this review was to summarize …

Endothelial cells (EC) are currently used as in vitro model systems for various physiological
and pathological processes, especially in angiogenesis research. Primary EC have a limited …

Background The vasculature of the brain is composed of endothelial cells, pericytes and
astrocytic processes. The endothelial cells are the critical interface between the blood and …

We have developed a renewable, scalable and transgene free human blood-brain barrier
model, composed of brain endothelial cells (BECs), generated from human amniotic fluid …

The passage of substances across the blood–brain barrier (BBB) is regulated in the cerebral
capillaries, which possess certain distinct different morphological and enzymatic properties …