Industrial Production of l-Ascorbic Acid (Vitamin C) and d-Isoascorbic Acid

G Pappenberger, HP Hohmann - Biotechnology of food and feed additives, 2014 - Springer
Abstract l-ascorbic acid (vitamin C) was first isolated in 1928 and subsequently identified as
the long-sought antiscorbutic factor. Industrially produced l-ascorbic acid is widely used in …

Current challenges facing one-step production of L-ascorbic acid

P Wang, W Zeng, S Xu, G Du, J Zhou, J Chen - Biotechnology Advances, 2018 - Elsevier
Abstract l-ascorbic acid (L-AA, vitamin C) is an essential vitamin that is widely used as a
nutrient or medicine in the pharmaceuticals, cosmetics, food, beverage and feed additive …

Addition of commercial probiotic in a biofloc shrimp farm of Litopenaeus vannamei during the nursery phase: effect on bacterial diversity using massive sequencing …

JA Huerta-Rábago, M Martínez-Porchas… - Aquaculture, 2019 - Elsevier
The aim of this study was to describe the effect of the addition of commercial probiotics on
the bacterial diversity in biofloc generated in a commercial farm of whiteleg shrimp …

Reorganization of a synthetic microbial consortium for one-step vitamin C fermentation

EX Wang, MZ Ding, Q Ma, XT Dong, YJ Yuan - Microbial cell factories, 2016 - Springer
Background In the industry, the conventional two-step fermentation method was used to
produce 2-keto-l-gulonic acid (2-KGA), the precursor of vitamin C, by three strains, namely …

One-Step Biosynthesis of Vitamin C in Saccharomyces cerevisiae

M Zhou, Y Bi, M Ding, Y Yuan - Frontiers in Microbiology, 2021 - frontiersin.org
Vitamin C (VC) is comprehensively applied in foods, cosmetics, pharmaceuticals, and
especially clinical medicine. Nowadays, the industrial production of VC mainly relies on the …

Industrial fermentation of vitamin C

W Yang, H Xu - Industrial biotechnology of vitamins …, 2016 - Wiley Online Library
L‐ascorbic acid (vitamin C), which was first isolated in 1928, is an essential nutrient for
humans and a few other mammals. Vitamin C is widely used in the food, beverage, animal …

Combinational expression of sorbose/sorbosone dehydrogenases and cofactor pyrroloquinoline quinone increases 2-keto-L-gulonic acid production in …

J Du, W Bai, H Song, YJ Yuan - Metabolic engineering, 2013 - Elsevier
The expression levels of sorbose/sorbosone dehydrogenase genes (sdh and sndh) and the
synthesis genes (pqqABCDEN) of the adjoint cofactor pyrroloquinoline quinone (PQQ) were …

Combined engineering of l-sorbose dehydrogenase and fermentation optimization to increase 2-keto-l-gulonic acid production in Escherichia coli

D Li, X Wang, Z Qin, S Yu, J Chen, J Zhou - Bioresource Technology, 2023 - Elsevier
One-step fermentation to produce 2-keto-l-gulonic acid (2-KLG), the precursor of vitamin C,
is a long-term goal. Improvement of the enzyme's activity through engineering could benefit …

Metabolic model reconstruction and analysis of an artificial microbial ecosystem for vitamin C production

C Ye, W Zou, N Xu, L Liu - Journal of biotechnology, 2014 - Elsevier
An artificial microbial ecosystem (AME) consisting of Ketogulonicigenium vulgare and
Bacillus megaterium is currently used in a two-step fermentation process for vitamin C …

Structure, mechanism and regulation of an artificial microbial ecosystem for vitamin C production

W Zou, L Liu, J Chen - Critical reviews in microbiology, 2013 - Taylor & Francis
At present, the modern two-step fermentation process is one of the major approaches for the
industrial production of vitamin C. The key step in this process is the conversion of L-sorbose …