Biomedical data, computational methods and tools for evaluating disease–disease associations

J Xiang, J Zhang, Y Zhao, FX Wu… - Briefings in …, 2022 - academic.oup.com
In recent decades, exploring potential relationships between diseases has been an active
research field. With the rapid accumulation of disease-related biomedical data, a lot of …

Partial order relation–based gene ontology embedding improves protein function prediction

W Li, B Wang, J Dai, Y Kou, X Chen… - Briefings in …, 2024 - academic.oup.com
Protein annotation has long been a challenging task in computational biology. Gene
Ontology (GO) has become one of the most popular frameworks to describe protein …

[HTML][HTML] Hyperbolic hierarchical knowledge graph embeddings for biological entities

N Li, Z Yang, Y Yang, J Wang, H Lin - Journal of Biomedical Informatics, 2023 - Elsevier
Predicting relationships between biological entities can greatly benefit important biomedical
problems. Previous studies have attempted to represent biological entities and relationships …

An experimental analysis of graph representation learning for Gene Ontology based protein function prediction

TTD Vu, J Kim, J Jung - PeerJ, 2024 - peerj.com
Understanding protein function is crucial for deciphering biological systems and facilitating
various biomedical applications. Computational methods for predicting Gene Ontology …

Subcellular location of source proteins improves prediction of neoantigens for immunotherapy

A Castro, S Kaabinejadian, H Yari, W Hildebrand… - The EMBO …, 2022 - embopress.org
Antigen presentation via the major histocompatibility complex (MHC) is essential for anti‐
tumor immunity. However, the rules that determine which tumor‐derived peptides will be …

gGN: Representing the Gene Ontology as low-rank Gaussian distributions

AA Edera, G Stegmayer, DH Milone - Computers in Biology and Medicine, 2024 - Elsevier
Computational representations of knowledge graphs are critical for several tasks in
bioinformatics, including large-scale graph analysis and gene function characterization. In …

A Self-Supervised Framework for Learning Biological Entities Representation by Fusing Class Information

N Li, Z Yang, J Wang, H Lin - IEEE Journal of Biomedical and …, 2023 - ieeexplore.ieee.org
Ontologies are widely utilized in the biological domain for data annotation, integration, and
analysis. Some representation learning methods have been proposed to learn the …

gGN: learning to represent graph nodes as low-rank Gaussian distributions

AA Edera, G Stegmayer, DH Milone - bioRxiv, 2022 - biorxiv.org
Unsupervised learning of node representations from knowledge graphs is critical for
numerous downstream tasks, ranging from large-scale graph analysis to measuring …

Prediction of Insufficient Accuracy for Patient's Length of Stay using Feed Forward Neural Network by comparing Deep Belief Network

CV Kumar, MS Saravanan… - 2023 Fifth International …, 2023 - ieeexplore.ieee.org
The research is to study the patient's length of stay in intensive care unit (ICU) admissions
each year with their cost and health expenditure. Forecasting in the clinical Decision …

Immunogenic potential of neopeptides depends on parent protein subcellular location

A Castro, S Kaabinejadian, W Hildebrand, M Zanetti… - bioRxiv, 2021 - biorxiv.org
Antigen presentation via the major histocompatibility complex (MHC) is essential for anti-
tumor immunity, however the rules that determine what tumor-derived peptides will be …