Pyroptosis is a lytic and inflammatory type of programmed cell death that is usually triggered
by inflammasomes and executed by gasdermin proteins. The main characteristics of …

Liver fibrosis is an abnormal wound repair response caused by a variety of chronic liver
injuries, which is characterized by over-deposition of diffuse extracellular matrix (ECM) and …

Nonalcoholic fatty liver disease (NAFLD) is a growing cause of chronic liver disease. Using
a proxy NAFLD definition of chronic elevation of alanine aminotransferase (cALT) levels …

Pyroptosis is a novel inflammatory form of regulated cell death (RCD), characterized by cell
swelling, membrane rupture, and pro-inflammatory effects. It is recognized as a potent …

Chronic liver injury with any etiology can progress to fibrosis and the end-stage diseases
cirrhosis and hepatocellular carcinoma. The progression of liver disease is controlled by a …

Interleukin‐18 signaling promotes activation of hepatic stel... : Hepatology Interleukin‐18
signaling promotes activation of hepatic stellate cells in mouse liver fibrosis : Hepatology AASLD …

Background: Treatment with the chemotherapy drug doxorubicin (DOX) may lead to
toxicities that affect non-cancer cells including the liver. Supplementing the diet with creatine …

Obesity is a prevalent predisposing factor to non-alcoholic fatty liver disease (NAFLD), the
most common chronic liver disease in the developed world. NAFLD spectrum of disease …

The NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome pathway is
mainly responsible for the activation and release of a cascade of proinflammatory mediators …

Liver fibrosis is the common pathological basis of all chronic liver diseases, and is the
necessary stage for the progression of chronic liver disease to cirrhosis. As one of …