In recent years, significant progress has been made in understanding the geometric and
electronic structures of the active sites of non-heme iron enzymes and the contributions of …

▪ Abstract Phenylalanine hydroxylase, tyrosine hydroxylase, and tryptophan hydroxylase
constitute a small family of monooxygenases that utilize tetrahydropterins as substrates …

Growing evidence supports a critical role of metal-ligand coordination in many attributes of
biological materials including adhesion, self-assembly, toughness, and hardness without …

Tyrosine hydroxylase (TH) catalyzes the rate-limiting step in the biosynthesis of dopamine
(DA) and other catecholamines, and its dysfunction leads to DA deficiency and …

Hydrogel systems based on cross-linked polymeric materials which could provide both
adhesion and cohesion in wet environment have been considered as a promising …

The emergence of new pathogens and multidrug resistant bacteria is an important public
health issue that requires the development of novel classes of antibiotics. Antimicrobial …

Aerobic life on our planet relies on the use of molecular oxygen for energy as well as for
biosynthesis of important biological compounds in metabolic pathways. Thermodynamically …

A consistent neurochemical abnormality in Parkinson's disease (PD) is degeneration of
dopaminergic neurons in substantia nigra, leading to a reduction of striatal dopamine (DA) …

Tetrahydrobiopterin-dependent systems occupy several interesting niches in biological
chemistry, as metalloproteins that activate O2 for highly specific oxidations, as regulators for …

This Handbook on Metalloproteins focuses on the available structural information of proteins
and their metal ion coordination spheres. It centers on the metal ions indispensable for life …