Restricting the intake of calories has been practiced as a method for increasing both the
length and quality of life for over 500years. Experimental work confirming the success of this …

Epidemiological, neuropathological, and functional neuroimaging evidence implicates
global and regional disruptions in brain metabolism and energetics in the pathogenesis of …

Dietary restriction has been shown to have several health benefits including increased
insulin sensitivity, stress resistance, reduced morbidity, and increased life span. The …

Background: Little is known about the association between eating patterns and type 2
diabetes (T2D) risk. Objective: The objective of this study was to prospectively examine …

Both calorie restriction and the ketogenic diet possess broad therapeutic potential in various
clinical settings and in various animal models of neurological disease. Following calorie …

Intermittent fasting (IF; reduced meal frequency) and caloric restriction (CR) extend lifespan
and increase resistance to age-related diseases in rodents and monkeys and improve the …

Neurotrophic factors are essential contributors to the survival of peripheral and central
nervous system (CNS) neurons, and demonstration of their reduced availability in diseased …

Multiple avenues of research including epidemiology, molecular genetics and cell biology
have identified links between Parkinson's disease and type 2 diabetes mellitus. Several …

Cognitive impairment and emotional disturbances in Alzheimer's disease (AD) result from
the degeneration of synapses and death of neurons in the limbic system and associated …

Multiple molecular, cellular, structural, and functional changes occur in the brain during
aging. Neural cells may respond to these changes adaptively, or they may succumb to …