Molecular mechanisms of biofilm-based antibiotic resistance and tolerance in pathogenic bacteria

CW Hall, TF Mah - FEMS microbiology reviews, 2017 - academic.oup.com
Biofilms are surface-attached groups of microbial cells encased in an extracellular matrix
that are significantly less susceptible to antimicrobial agents than non-adherent, planktonic …

Clinical significance and pathogenesis of staphylococcal small colony variants in persistent infections

BC Kahl, K Becker, B Löffler - Clinical microbiology reviews, 2016 - Am Soc Microbiol
Small colony variants (SCVs) were first described more than 100 years ago for
Staphylococcus aureus and various coagulase-negative staphylococci. Two decades ago …

Bacterial stress responses as determinants of antimicrobial resistance

K Poole - Journal of Antimicrobial Chemotherapy, 2012 - academic.oup.com
Bacteria encounter a myriad of stresses in their natural environments, including, for
pathogens, their hosts. These stresses elicit a variety of specific and highly regulated …

Staphylococcus aureus phenotype switching: an effective bacterial strategy to escape host immune response and establish a chronic infection

L Tuchscherr, E Medina, M Hussain… - EMBO molecular …, 2011 - embopress.org
Staphylococcus aureus is a frequent cause for serious, chronic and therapy‐refractive
infections in spite of susceptibility to antibiotics in vitro. In chronic infections, altered bacterial …

Sigma Factor SigB Is Crucial to Mediate Staphylococcus aureus Adaptation during Chronic Infections

L Tuchscherr, M Bischoff, SM Lattar… - PLoS …, 2015 - journals.plos.org
Staphylococcus aureus is a major human pathogen that causes a range of infections from
acute invasive to chronic and difficult-to-treat. Infection strategies associated with persisting …

Persistence of Staphylococcus aureus: Multiple Metabolic Pathways Impact the Expression of Virulence Factors in Small-Colony Variants (SCVs)

L Tuchscherr, B Löffler, RA Proctor - Frontiers in Microbiology, 2020 - frontiersin.org
Staphylococcus aureus is able to survive within host cells by switching its phenotype to the
small-colony variant (SCV) phenotype. The emergence of SCVs is associated with the …

Antibiotic activity against small-colony variants of Staphylococcus aureus: review of in vitro, animal and clinical data

LG Garcia, S Lemaire, BC Kahl, K Becker… - Journal of …, 2013 - academic.oup.com
The pathogen Staphylococcus aureus uses various strategies for persisting in the host,
among which switching to a small-colony variant (SCV) phenotype is of particular biological …

Staphylococcus aureus persistence properties associated with bovine mastitis and alternative therapeutic modalities

N Zaatout, A Ayachi, M Kecha - Journal of applied microbiology, 2020 - academic.oup.com
Staphylococcus aureus is an important agent of contagious bovine intramammary infections
in dairy cattle. Its ability to persist inside the udder is based on the presence of important …

Staphylococcus aureus Adapts to Oxidative Stress by Producing H2O2-Resistant Small-Colony Variants via the SOS Response

KL Painter, E Strange, J Parkhill, KB Bamford… - Infection and …, 2015 - Am Soc Microbiol
The development of chronic and recurrent Staphylococcus aureus infections is associated
with the emergence of slow-growing mutants known as small-colony variants (SCVs), which …

Staphylococcus aureus sigma B-dependent emergence of small-colony variants and biofilm production following exposure to Pseudomonas aeruginosa 4-hydroxy-2 …

G Mitchell, DL Séguin, AE Asselin, E Déziel… - BMC microbiology, 2010 - Springer
Abstract Background Staphylococcus aureus and Pseudomonas aeruginosa are often found
together in the airways of cystic fibrosis (CF) patients. It was previously shown that the P …