Cannabinoid receptors: where they are and what they do

K Mackie - Journal of neuroendocrinology, 2008 - Wiley Online Library
The endocannabinoid system consists of the endogenous cannabinoids
(endocannabinoids), cannabinoid receptors and the enzymes that synthesise and degrade …

Targeting the endocannabinoid system: to enhance or reduce?

V Di Marzo - Nature reviews Drug discovery, 2008 - nature.com
As our understanding of the endocannabinoids improves, so does the awareness of their
complexity. During pathological states, the levels of these mediators in tissues change, and …

Reversible and regionally selective downregulation of brain cannabinoid CB1 receptors in chronic daily cannabis smokers

J Hirvonen, RS Goodwin, CT Li, GE Terry… - Molecular …, 2012 - nature.com
Chronic cannabis (marijuana, hashish) smoking can result in dependence. Rodent studies
show reversible downregulation of brain cannabinoid CB 1 (cannabinoid receptor type 1) …

Effect of rimonabant on progression of atherosclerosis in patients with abdominal obesity and coronary artery disease: the STRADIVARIUS randomized controlled trial

SE Nissen, SJ Nicholls, K Wolski, J Rodés-Cabau… - Jama, 2008 - jamanetwork.com
Context Abdominal obesity is associated with metabolic abnormalities and increased risk of
atherosclerotic cardiovascular disease. However, no obesity management strategy has …

The metabolic syndrome—from insulin resistance to obesity and diabetes

EJ Gallagher, D LeRoith, E Karnieli - Endocrinology and metabolism clinics …, 2008 - Elsevier
In today's society with the escalating levels of obesity, diabetes, and cardiovascular disease,
the metabolic syndrome is receiving considerable attention and is the subject of much …

Cannabinoids and the immune system: an overview

R Tanasescu, CS Constantinescu - Immunobiology, 2010 - Elsevier
Cannabinoids can influence the immune network. Data on the impact of exogenous
cannabinoid ligands on immune function serve not only to understand how the …

Endocannabinoid system: a multi-facet therapeutic target

R Kaur, SR Ambwani, S Singh - Current clinical pharmacology, 2016 - ingentaconnect.com
Cannabis sativa is also popularly known as marijuana. It has been cultivated and used by
man for recreational and medicinal purposes since many centuries. Study of cannabinoids …

CNS regulation of appetite

JA Harrold, TM Dovey, JE Blundell, JCG Halford - Neuropharmacology, 2012 - Elsevier
This article reviews the regulation of appetite from a biopsychological perspective. It
considers psychological experiences and peripheral nutritional systems (both episodic and …

Physiological, pharmacological, and nutritional regulation of circulating adiponectin concentrations in humans

MM Swarbrick, PJ Havel - Metabolic syndrome and related …, 2008 - liebertpub.com
Adiponectin is an adipocyte hormone that links visceral adiposity with insulin resistance and
atherosclerosis. It is unique among adipocyte-derived hormones in that its circulating …

Obesity affects the microbiota–gut–brain axis and the regulation thereof by endocannabinoids and related mediators

N Forte, AC Fernández-Rilo, L Palomba… - International Journal of …, 2020 - mdpi.com
The hypothalamus regulates energy homeostasis by integrating environmental and internal
signals to produce behavioral responses to start or stop eating. Many satiation signals are …