[HTML][HTML] Computational modeling of cardiac electrophysiology and arrhythmogenesis: toward clinical translation
The complexity of cardiac electrophysiology, involving dynamic changes in numerous
components across multiple spatial (from ion channel to organ) and temporal (from …
components across multiple spatial (from ion channel to organ) and temporal (from …
Computational modeling of cardiac electrophysiology and arrhythmogenesis: toward clinical translation
The complexity of cardiac electrophysiology, involving dynamic changes in numerous
components across multiple spatial (from ion channel to organ) and temporal (from …
components across multiple spatial (from ion channel to organ) and temporal (from …
A computational model of induced pluripotent stem-cell derived cardiomyocytes for high throughput risk stratification of KCNQ1 genetic variants
In the last decade, there has been tremendous progress in identifying genetic anomalies
linked to clinical disease. New experimental platforms have connected genetic variants to …
linked to clinical disease. New experimental platforms have connected genetic variants to …
Data-driven uncertainty quantification for cardiac electrophysiological models: impact of physiological variability on action potential and spiral wave dynamics
P Pathmanathan, SK Galappaththige… - Frontiers in …, 2020 - frontiersin.org
Computational modeling of cardiac electrophysiology (EP) has recently transitioned from a
scientific research tool to clinical applications. To ensure reliability of clinical or regulatory …
scientific research tool to clinical applications. To ensure reliability of clinical or regulatory …
Beta-adrenergic receptor stimulation modulates the cellular proarrhythmic effects of chloroquine and azithromycin
The antimalarial drug, chloroquine (CQ), and antimicrobial drug, azithromycin (AZM), have
received significant attention during the COVID-19 pandemic. Both drugs can alter cardiac …
received significant attention during the COVID-19 pandemic. Both drugs can alter cardiac …
Integrative human atrial modelling unravels interactive protein kinase A and Ca2+/calmodulin-dependent protein kinase II signalling as key determinants of atrial …
Aims Atrial fibrillation (AF), the most prevalent clinical arrhythmia, is associated with atrial
remodelling manifesting as acute and chronic alterations in expression, function, and …
remodelling manifesting as acute and chronic alterations in expression, function, and …
The role of β-adrenergic stimulation in QT interval adaptation to heart rate during stress test
C Pérez, R Cebollada, KA Mountris, JP Martínez… - Plos one, 2023 - journals.plos.org
The adaptation lag of the QT interval after heart rate (HR) has been proposed as an
arrhythmic risk marker. Most studies have quantified the QT adaptation lag in response to …
arrhythmic risk marker. Most studies have quantified the QT adaptation lag in response to …
[HTML][HTML] Remodelling of potassium currents underlies arrhythmic action potential prolongation under beta-adrenergic stimulation in hypertrophic cardiomyopathy
R Doste, R Coppini, A Bueno-Orovio - Journal of Molecular and Cellular …, 2022 - Elsevier
Hypertrophic cardiomyopathy (HCM) patients often present an enhanced arrhythmogenicity
that can lead to lethal arrhythmias, especially during exercise. Recent studies have …
that can lead to lethal arrhythmias, especially during exercise. Recent studies have …
[HTML][HTML] The role of β-adrenergic system remodeling in human heart failure: A mechanistic investigation
Abstract β-adrenergic receptor antagonists (β-blockers) are extensively used to improve
cardiac performance in heart failure (HF), but the electrical improvements with these clinical …
cardiac performance in heart failure (HF), but the electrical improvements with these clinical …
Integrative human atrial modeling unravels interactive PKA and CaMKII signaling as key determinant of atrial arrhythmogenesis
Atrial fibrillation (AF), the most prevalent clinical arrhythmia, is associated with atrial
remodeling manifesting as acute and chronic alterations in expression, function, and …
remodeling manifesting as acute and chronic alterations in expression, function, and …