Emerging evidence suggests that liquid–liquid phase separation (LLPS) represents a vital
and ubiquitous phenomenon underlying the formation of membraneless organelles in …

The MYC protooncogene functions as a universal amplifier of transcription through
interaction with numerous factors and complexes that regulate almost every cellular process …

Cells are compartmentalized by numerous membrane-enclosed organelles and
membraneless compartments to ensure that a wide variety of cellular activities occur in a …

In response to stress, human cells coordinately downregulate transcription and translation of
housekeeping genes. To downregulate transcription, the negative elongation factor (NELF) …

R-loops are non-B DNA structures that form during transcription when the nascent RNA
anneals to the template DNA strand forming a RNA: DNA hybrid. Understanding the …

It is essential for cells to control which genes are transcribed into RNA. In eukaryotes, two
major control points are recruitment of RNA polymerase II (Pol II) into a paused state, and …

SPT6 is a histone chaperone that tightly binds RNA polymerase II (RNAPII) during
transcription elongation. However, its primary role in transcription is uncertain. We used …

Transcription by RNA polymerase II (Pol II) is coupled to pre-mRNA splicing, but the
underlying mechanisms remain poorly understood. Co-transcriptional splicing requires …

Multi-dimensional omics profiling continues to illuminate the complexity of cellular
processes. Because of difficult mechanistic interpretation of phenotypes induced by slow …

Cellular DNA is continuously transcribed into RNA by multisubunit RNA polymerases
(RNAPs). The continuity of transcription can be disrupted by DNA lesions that arise from the …