Evolution of the adaptogenic concept from traditional use to medical systems: Pharmacology of stress‐and aging‐related diseases

AG Panossian, T Efferth, AN Shikov… - Medicinal research …, 2021 - Wiley Online Library
Adaptogens comprise a category of herbal medicinal and nutritional products promoting
adaptability, resilience, and survival of living organisms in stress. The aim of this review was …

[HTML][HTML] NRF2 and NF-қB interplay in cerebrovascular and neurodegenerative disorders: molecular mechanisms and possible therapeutic approaches

F Sivandzade, S Prasad, A Bhalerao, L Cucullo - Redox biology, 2019 - Elsevier
Electrophiles and reactive oxygen species (ROS) play a major role in modulating cellular
defense mechanisms as well as physiological functions, and intracellular signaling …

Neuroinflammation in Parkinson's disease: its role in neuronal death and implications for therapeutic intervention

MG Tansey, MS Goldberg - Neurobiology of disease, 2010 - Elsevier
Parkinson's disease (PD) is the second most common neurodegenerative disease, after
Alzheimer's disease. The potential causes of PD remain uncertain, but recent studies …

Multiplicity of effects and health benefits of resveratrol

L Kuršvietienė, I Stanevičienė, A Mongirdienė… - Medicina, 2016 - mdpi.com
Resveratrol is mainly found in grapes and red wine, also in some plants and fruits, such as
peanuts, cranberries, pistachios, blueberries and bilberries. Moreover, nowadays this …

Role of NF-κB in ageing and age-related diseases: lessons from genetically modified mouse models

VA García-García, JP Alameda, A Page, ML Casanova - Cells, 2021 - mdpi.com
Ageing is a complex process, induced by multifaceted interaction of genetic, epigenetic, and
environmental factors. It is manifested by a decline in the physiological functions of …

Role of nuclear factor kappa B (NF-κB) signalling in neurodegenerative diseases: an mechanistic approach

S Singh, TG Singh - Current Neuropharmacology, 2020 - ingentaconnect.com
A transcriptional regulatory nuclear factor kappa B (NF-ΚB) protein is a modulator of cellular
biological activity via binding to a promoter region in the nucleus and transcribing various …

[HTML][HTML] Dietary polyphenols as modulators of brain functions: biological actions and molecular mechanisms underpinning their beneficial effects

D Vauzour - Oxidative medicine and cellular longevity, 2012 - hindawi.com
Accumulating evidence suggests that diet and lifestyle can play an important role in delaying
the onset or halting the progression of age-related health disorders and to improve cognitive …

Activation of innate immunity system during aging: NF-kB signaling is the molecular culprit of inflamm-aging

A Salminen, J Huuskonen, J Ojala, A Kauppinen… - Ageing research …, 2008 - Elsevier
Innate and adaptive immunity are the major defence mechanisms of higher organisms
against inherent and environmental threats. Innate immunity is present already in unicellular …

[PDF][PDF] The stressed CNS: when glucocorticoids aggravate inflammation

SF Sorrells, JR Caso, CD Munhoz, RM Sapolsky - Neuron, 2009 - cell.com
Glucocorticoids (GCs) are hormones released during the stress response that are well
known for their immunosuppressive and anti-inflammatory properties; however, recent …

Nuclear factor‐kappa β as a therapeutic target for Alzheimer's disease

NK Jha, SK Jha, R Kar, P Nand, K Swati… - Journal of …, 2019 - Wiley Online Library
Alzheimer's disease (AD) is a typical progressive, chronic neurodegenerative disorder with
worldwide prevalence. Its clinical manifestation involves the presence of extracellular …