Despite over 40 years following the first birth from medically assisted reproduction (MAR)
technologies, mechanisms underlying the key developmental events during the first 7 days …

The use of stem cells to model the early human embryo promises to transform our
understanding of developmental biology and human reproduction. In this review, we present …

STUDY QUESTION Which processes and transcription factors specify the first and second
lineage segregation events during human preimplantation development? SUMMARY …

Extraembryonic tissues have pivotal roles in morphogenesis and patterning of the early
mammalian embryo. Developmental programmes mediated through signalling pathways …

CRISPR-Cas ribonucleoproteins (RNPs) are important tools for gene editing in
preimplantation embryos. However, the inefficient production of biallelic deletions in cattle …

In the first days of life, cells of the mammalian embryo segregate into two distinct lineages,
trophectoderm and inner cell mass. Unlike nonmammalian species, mammalian …

To implant in the uterus, mammalian embryos form blastocysts comprising trophectoderm
(TE) surrounding an inner cell mass (ICM), confined to the polar region by the expanding …

In recent years, the pursuit of inducing the trophoblast stem cell (TSC) state has gained
prominence as a compelling research objective, illuminating the establishment of the …

Studies in the mouse demonstrate the importance of fibroblast growth factor (FGF) and extra-
cellular receptor tyrosine kinase (ERK) in specification of embryo-fated epiblast and yolk-sac …

Simple Summary In this study, we investigated the critical process of cell fate determination
in mouse embryos, focusing on the transition from embryonic stem cells (ESC) to trophoblast …