Glial fibrillary acidic protein (GFAP) is the main intermediate filament protein in mature
astrocytes, but also an important component of the cytoskeleton in astrocytes during …

Intermediate filaments are critical for cell and tissue homeostasis and for stress responses.
Cytoplasmic intermediate filaments form versatile and dynamic assemblies that interconnect …

Human epithelial cells contain, intermediate-sized filaments formed by polypeptides related
to epidermal α-keratin (“cytokeratins”) which are expressed in different combinations in …

Cytokeratins are a large multigene family comprising two polypeptide types, ie acidic (type I)
and basic (type II) ones, which are distinguished on the basis of immunological, peptide …

Intermediate filaments (IFs) are involved in key cellular functions including polarization,
migration, and protection against large deformations. These functions are related to their …

Glial fibrillary acidic protein (GFAP) is an intermediate filament protein specifically expressed
in astrocytes in the CNS. To examine the function of GFAP in vivo, the Gfap gene was …

Recently, it has been shown that the early developmental organization of the archicortical
hippocampus resembles that of the neocortex. In both cortices at embryonic stages, a …

The distribution and time course of postischemic astrocyte hypertrophy and hyperplasia and
the relationship to neuronal viability or necrosis was studied in rats subjected to 30 min of …

Here we review how GFAP mutations cause Alexander disease. The current data suggest
that a combination of events cause the disease. These include:(i) the accumulation of GFAP …

Intermediate-sized filaments (IF) are among the most insoluble intracellular protein polymer
structures. We have analyzed the small amounts of soluble vimentin, an IF protein, present …