Engineering cocrystals of poorly water-soluble drugs to enhance dissolution in aqueous medium

I Sathisaran, SV Dalvi - Pharmaceutics, 2018 - mdpi.com
Biopharmaceutics Classification System (BCS) Class II and IV drugs suffer from poor
aqueous solubility and hence low bioavailability. Most of these drugs are hydrophobic and …

Intermolecular interactions in functional crystalline materials: from data to knowledge

AV Vologzhanina - Crystals, 2019 - mdpi.com
Intermolecular interactions of organic, inorganic, and organometallic compounds are the key
to many composition–structure and structure–property networks. In this review, some of …

Eutectics as improved pharmaceutical materials: design, properties and characterization

S Cherukuvada, A Nangia - Chemical Communications, 2014 - pubs.rsc.org
Eutectics are a long known class of multi-component solids with important and useful
applications in daily life. In comparison to other multi-component crystalline solids, such as …

Rational modification of the hierarchy of intermolecular interactions in molecular crystal structures by using tunable halogen bonds

G Mínguez Espallargas, F Zordan… - … A European Journal, 2009 - Wiley Online Library
A family of 16 isomolecular salts (3‐XpyH) 2 [MX′ 4](3‐XpyH= 3‐halopyridinium; M= Co,
Zn; X=(F), Cl, Br,(I); X′= Cl, Br, I) each containing rigid organic cations and tetrahedral …

Synthesis of ternary cocrystals, salts, and hydrates of acefylline with enhanced dissolution and high permeability

S Allu, A Garai, VV Chernyshev… - Crystal Growth & …, 2022 - ACS Publications
Acefylline (ACF) is a stimulant xanthine derivative drug, which is formulated as a piperazine
salt for the treatment of bronchial asthma. ACF falls under BCS class IV category of low …

[HTML][HTML] Isomorphism:molecular similarity to crystal structure similarity'in multicomponent forms of analgesic drugs tolfenamic and mefenamic acid

S Ranjan, R Devarapalli, S Kundu, S Saha, S Deolka… - IUCrJ, 2020 - scripts.iucr.org
The non-steroidal anti-inflammatory drugs mefenamic acid (MFA) and tolfenamic acid (TFA)
have a close resemblance in their molecular scaffold, whereby a methyl group in MFA is …

Influence of substituents in the aromatic ring on the strength of halogen bonding in iodobenzene derivatives

MV Chernysheva, M Bulatova, X Ding… - Crystal Growth & …, 2020 - ACS Publications
The halogen-bonding properties of 3, 4, 5-triiodobenzoic acid (1, 2), 1, 2, 3-triiodobenzene
(3), 4-iodobenzoic acid (4), pentaiodobenzoic acid ethanol solvate (5), hexaiodobenzene …

Cl··· Cl interactions in molecular crystals: Insights from the theoretical charge density analysis

MV Vener, AV Shishkina, AA Rykounov… - The Journal of …, 2013 - ACS Publications
The structure, IR harmonic frequencies and intensities of normal vibrations of 20 molecular
crystals with the X–Cl··· Cl–X contacts of different types, where X= C, Cl, and F and the Cl …

The role of π-stacking in the composition of phloroglucinol and phenazine cocrystals

B Sarma, LS Reddy, A Nangia - Crystal Growth and Design, 2008 - ACS Publications
Cocrystallization of phloroglucinol (PHG) and phenazine (Phen) afforded cocrystals of 1: 1.5,
1: 1.75, and 1: 2 PHG· Phen stoichiometry upon grinding the two components in different …

Clofazimine mesylate: a high solubility stable salt

G Bolla, A Nangia - Crystal growth & design, 2012 - ACS Publications
Clofazimine (CFZ), an antibacterial and anti-inflammatory drug, is also recommended by the
World Health Organization for the treatment of leprosy in combination with dapsone and …