Recent strategies and advances in the fabrication of nano lipid carriers and their application towards brain targeting

M Agrawal, S Saraf, S Saraf, SK Dubey, A Puri… - Journal of Controlled …, 2020 - Elsevier
In last two decades, the lipid nanocarriers have been extensively investigated for their drug
targeting efficiency towards the critical areas of the human body like CNS, cardiac region …

Increased mortality in schizophrenia due to cardiovascular disease–a non-systematic review of epidemiology, possible causes, and interventions

PA Ringen, JA Engh, AB Birkenaes, I Dieset… - Frontiers in …, 2014 - frontiersin.org
Background: Schizophrenia is among the major causes of disability worldwide and the
mortality from cardiovascular disease (CVD) is significantly elevated. There is a growing …

Antipsychotic drugs: from receptor-binding profiles to metabolic side effects

S Siafis, D Tzachanis, M Samara… - Current …, 2018 - ingentaconnect.com
Background: Antipsychotic-induced metabolic side effects are major concerns in
psychopharmacology and clinical psychiatry. Their pathogenetic mechanisms are still not …

The current status of the ketogenic diet in psychiatry

ECS Bostock, KC Kirkby, BVM Taylor - Frontiers in psychiatry, 2017 - frontiersin.org
Background The ketogenic diet (KD) has been used in treatment-resistant epilepsy since the
1920s. It has been researched in a variety of neurological conditions in both animal models …

Characterizing the shared genetic underpinnings of schizophrenia and cardiovascular disease risk factors

L Rødevand, Z Rahman, GFL Hindley… - American Journal of …, 2023 - Am Psychiatric Assoc
Objective: Schizophrenia is associated with increased risk of cardiovascular disease (CVD),
although there is variation in risk among individuals. There are indications of shared genetic …

Targeted placental deletion of OGT recapitulates the prenatal stress phenotype including hypothalamic mitochondrial dysfunction

CL Howerton, TL Bale - Proceedings of the National …, 2014 - National Acad Sciences
Maternal stress is a key risk factor in neurodevelopmental disorders, which often have a sex
bias in severity and prevalence. We previously identified O-GlcNAc transferase (OGT) as a …

Omics-based biomarkers: application of metabolomics in neuropsychiatric disorders

S Sethi, E Brietzke - International Journal of …, 2016 - academic.oup.com
One of the major concerns of modern society is to identify putative biomarkers that serve as
a valuable early diagnostic tool to identify a subset of patients with increased risk to develop …

[PDF][PDF] and type 2 diabetes mellitus

V Mamakou, A Thanopoulou… - ΕΛΛΗΝΙΚΗ …, 2018 - psychiatriki-journal.gr
Schizophrenia is associated with increased risk for type 2 diabetes mellitus, resulting in
elevated cardiovascular risk and limited life expectancy, translated into a weighted average …

Role of immunological factors in the pathophysiology and diagnosis of bipolar disorder: comparison with schizophrenia

AC Altamura, M Buoli, S Pozzoli - Psychiatry and clinical …, 2014 - Wiley Online Library
Several lines of evidence point to the key role of neurobiological mechanisms and shared
genetic background in schizophrenia and bipolar disorder. For both disorders …

Crosstalk between schizophrenia and metabolic syndrome: The role of oxytocinergic dysfunction

KK Goh, CYA Chen, TH Wu, CH Chen… - International journal of …, 2022 - mdpi.com
The high prevalence of metabolic syndrome in persons with schizophrenia has spurred
investigational efforts to study the mechanism beneath its pathophysiology. Early psychosis …