Early in the 1980s several laboratories mistakenly reported that partially purified interleukin-
1 (IL-1) was chemotactic for neutrophils. However, further investigations by us, revealed that …

Neutrophils are immune cells with unusual biological features that furnish potent
antimicrobial properties. These cells phagocytose and subsequently kill prokaryotic and …

Trained immunity is a functional state of the innate immune response and is characterized
by long-term epigenetic reprogramming of innate immune cells. This concept originated in …

Increasing evidence indicates that the brain regulates peripheral immunity, yet whether and
how the brain represents the state of the immune system remains unclear. Here, we show …

Macrophages, which are key cellular components of the liver, have emerged as essential
players in the maintenance of hepatic homeostasis and in injury and repair processes in …

SARS-CoV-2 infection poses a major threat to the lungs and multiple other organs,
occasionally causing death. Until effective vaccines are developed to curb the pandemic, it …

Neutrophils are the most abundant circulating leukocytes, being the first line of defence
against bacterial and fungal infections. However, neutrophils also contribute to tissue …

Recognizing the importance of leukocyte trafficking in inflammation led to some therapeutic
breakthroughs. However, many inflammatory pathologies remain without specific therapy …

Neutrophils have always been considered as uncomplicated front-line troopers of the innate
immune system equipped with limited proinflammatory duties. Yet recently, the role of the …

Neutrophils are frontline cells of the innate immune system. These effector leukocytes are
equipped with intriguing antimicrobial machinery and consequently display high cytotoxic …