Atherosclerosis is a chronic inflammatory disease of the arterial wall, characterized by the
formation of plaques containing lipid, connective tissue and immune cells in the intima of …

Atherosclerosis is the root cause of many cardiovascular diseases. Extensive research in
preclinical models and emerging evidence in humans have established the crucial roles of …

Recent advances have greatly improved our understanding of the molecular mechanisms
behind atherosclerosis pathogenesis. However, there is still a need to systematize this data …

In atherosclerosis, some regulatory T (Treg) cells become exTreg cells. We crossed
inducible Treg and exTreg cell lineage-tracker mice (FoxP3 eGFP− Cre-ERT2 ROSA26 CAG …

Age-related T cell dysfunction can lead to failure of immune tolerance mechanisms, resulting
in aberrant T cell-driven cytokine and cytotoxic responses that ultimately cause tissue …

Inflammation is intimately involved at all stages of atherosclerosis and remains a substantial
residual cardiovascular risk factor in optimally treated patients. The proof of concept that …

Atherosclerosis is a lipid-driven chronic inflammatory disease; however, whether it can be
classified as an autoimmune disease remains unclear. In this study, we applied single-cell T …

Background: Coronary artery disease is an incurable, life-threatening disease that was once
considered primarily a disorder of lipid deposition. Coronary artery disease is now also …

Background: In the past years, several studies investigated how distinct immune cell subsets
affects post–myocardial infarction repair. However, whether and how the tissue environment …

The advent of single-cell biology opens a new chapter for understanding human biological
processes and for diagnosing, monitoring, and treating disease. This revolution now …