1, 1, 1, 3, 3, 3-Hexafluoroisopropanol (HFIP) is a polar, strongly hydrogen bond-donating
solvent that has found numerous uses in organic synthesis due to its ability to stabilize ionic …

This Perspective surveys the progress and current limitations of nucleophilic fluorination
methodologies. Despite the long and rich history of C (sp3)–F bond construction in chemical …

The 2, 3-dihydrobenzofuran scaffold is widely found in natural products and biologically
active compounds. Herein, dearomatizing 2, 3-fluoroaroylation of benzofurans with aroyl …

1. INTRODUCTION Despite being largely absent from natural products and biological
processes, fluorine plays a conspicuous and increasingly important role within …

Taking into account the vast arrays of fluorinated motifs known, 11 this review will be limited
to the monofluorination of organic compounds, ie, synthetic methods allowing the …

Chiral salen–metal complexes are among the most versatile asymmetric catalysts and have
found utility in fields ranging from materials chemistry to organic synthesis. These complexes …

In this Review, we summarize the current state of the art in late‐transition‐metal‐catalyzed
reactions of acyl fluorides, covering both their synthesis and further transformations. In …

Increasing interest in C (sp3)–H bond functionalization has led to a multitude of recent
advances in intramolecular C (sp3)–H amination. Direct, intramolecular C (sp3)–N bond …

Potassium fluoride (KF) is an ideal reagent for fluorination because it is safe, easy to handle
and low-cost. However, poor solubility in organic solvents coupled with limited strategies to …

The review covers various aspects of fluorinated cycloalkyl (C3− C7) building blocks for drug
discovery, including their synthesis, key physicochemical properties, and biological and …