IL-9 aggravates SARS-CoV-2 infection and exacerbates associated airway inflammation

S Sadhu, R Dalal, J Dandotiya, A Binayke… - Nature …, 2023 - nature.com
SARS-CoV-2 infection is known for causing broncho-alveolar inflammation. Interleukin 9 (IL-
9) induces airway inflammation and bronchial hyper responsiveness in respiratory viral …

Golden Syrian hamster as a model to study cardiovascular complications associated with SARS-CoV-2 infection

ZA Rizvi, R Dalal, S Sadhu, A Binayke, J Dandotiya… - Elife, 2022 - elifesciences.org
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in the Golden
Syrian hamster causes lung pathology that resembles human coronavirus disease (COVID …

Pharmacological potential of Withania somnifera (L.) Dunal and Tinospora cordifolia (Willd.) Miers on the experimental models of COVID-19, T cell differentiation …

ZA Rizvi, P Babele, U Madan, S Sadhu… - Frontiers in …, 2023 - frontiersin.org
Cytokine release syndrome (CRS) due to severe acute respiratory coronavirus-2 (SARS-
CoV-2) infection leads to life-threatening pneumonia which has been associated with …

[HTML][HTML] A Systematic Assessment of Leishmania donovani Infection in Domestic and Wild Animal Reservoir Hosts of Zoonotic Visceral Leishmaniasis in India

GD Ghouse Peer, A Priyadarshini, A Gupta… - Microbiology …, 2024 - mdpi.com
Leishmaniasis is a neglected disease with a global spread that affects both domestic and
wild animals in addition to people. Leishmania donovani is the suspected anthroponotic …

Nanobiotics and the One Health Approach: Boosting the Fight against Antimicrobial Resistance at the Nanoscale

Himanshu, R Mukherjee, J Vidic, E Leal, AC da Costa… - Biomolecules, 2023 - mdpi.com
Antimicrobial resistance (AMR) is a growing public health concern worldwide, and it poses a
significant threat to human, animal, and environmental health. The overuse and misuse of …

Omicron sub-lineage BA. 5 infection results in attenuated pathology in hACE2 transgenic mice

ZA Rizvi, J Dandotiya, S Sadhu, R Khatri… - Communications …, 2023 - nature.com
A recently emerged sub-lineage of Omicron, BA. 5, together with BA. 4, caused a fifth wave
of coronavirus disease (COVID-19) in South Africa and subsequently emerged as a …

Proinflammatory innate cytokines and distinct metabolomic signatures shape the T cell response in active COVID-19

A Binayke, A Zaheer, J Dandotiya, SK Gupta, S Mani… - Vaccines, 2022 - mdpi.com
The underlying factors contributing to the evolution of SARS-CoV-2-specific T cell responses
during COVID-19 infection remain unidentified. To address this, we characterized innate and …

Identification of kinase inhibitors as potential host-directed therapies for intracellular bacteria

RHGA van den Biggelaar, KV Walburg… - Scientific Reports, 2024 - nature.com
The emergence of antimicrobial resistance has created an urgent need for alternative
treatments against bacterial pathogens. Here, we investigated kinase inhibitors as potential …

An Untargeted LC–MS based approach for identification of altered metabolites in blood plasma of rheumatic heart disease patients

S Das, Y Kumar, S Sharma, R Ray, S Arava, S Seth… - Scientific Reports, 2022 - nature.com
Rheumatic heart disease (RHD) is often considered as a disease of developing countries
and India is the home of about 40% of RHD patients. Environment seems to play a major …

Fangchinoline inhibits SARS-CoV-2 and MERS-CoV entry

S Sadhu, J Dandotiya, R Dalal, R Khatri, AZ Mykytyn… - Antiviral research, 2023 - Elsevier
The COVID-19 pandemic caused by SARS-CoV-2, lead to mild to severe respiratory illness
and resulted in 6.9 million deaths worldwide. Although vaccines are effective in preventing …