Integrins and cancer: regulators of cancer stemness, metastasis, and drug resistance
Interactions between cancer cells and their surroundings can trigger essential signaling
cues that determine cell fate and influence the evolution of the malignant phenotype. As the …
cues that determine cell fate and influence the evolution of the malignant phenotype. As the …
Cytoskeletal dynamics: a view from the membrane
M Bezanilla, AS Gladfelter, DR Kovar, WL Lee - Journal of Cell Biology, 2015 - rupress.org
Many aspects of cytoskeletal assembly and dynamics can be recapitulated in vitro; yet, how
the cytoskeleton integrates signals in vivo across cellular membranes is far less understood …
the cytoskeleton integrates signals in vivo across cellular membranes is far less understood …
Tumor-associated macrophages-derived exosomes promote the migration of gastric cancer cells by transfer of functional Apolipoprotein E
P Zheng, Q Luo, W Wang, J Li, T Wang, P Wang… - Cell death & …, 2018 - nature.com
Tumor-associated macrophages (TAMs) are a major component of the tumor
microenvironment and have been shown to contribute to tumor aggressiveness. However …
microenvironment and have been shown to contribute to tumor aggressiveness. However …
Profilin regulates F-actin network homeostasis by favoring formin over Arp2/3 complex
C Suarez, RT Carroll, TA Burke, JR Christensen… - Developmental cell, 2015 - cell.com
Fission yeast cells use Arp2/3 complex and formin to assemble diverse filamentous actin (F-
actin) networks within a common cytoplasm for endocytosis, division, and polarization …
actin) networks within a common cytoplasm for endocytosis, division, and polarization …
Actin stress fiber organization promotes cell stiffening and proliferation of pre-invasive breast cancer cells
Studies of the role of actin in tumour progression have highlighted its key contribution in cell
softening associated with cell invasion. Here, using a human breast cell line with conditional …
softening associated with cell invasion. Here, using a human breast cell line with conditional …
Internetwork competition for monomers governs actin cytoskeleton organization
Cells precisely control the formation of dynamic actin cytoskeleton networks to coordinate
fundamental processes, including motility, division, endocytosis and polarization. To support …
fundamental processes, including motility, division, endocytosis and polarization. To support …
A human organotypic microfluidic tumor model permits investigation of the interplay between patient-derived fibroblasts and breast cancer cells
Tumor–stroma interactions significantly influence cancer cell metastasis and disease
progression. These interactions are partly comprised of the cross-talk between tumor and …
progression. These interactions are partly comprised of the cross-talk between tumor and …
Profilin and formin constitute a pacemaker system for robust actin filament growth
The actin cytoskeleton drives many essential biological processes, from cell morphogenesis
to motility. Assembly of functional actin networks requires control over the speed at which …
to motility. Assembly of functional actin networks requires control over the speed at which …
RNA splicing analysis deciphers developmental hierarchies and reveals therapeutic targets in adult glioma
Widespread alterations in RNA alternative splicing (AS) have been identified in adult
gliomas. However, their regulatory mechanism, biological significance, and therapeutic …
gliomas. However, their regulatory mechanism, biological significance, and therapeutic …
[HTML][HTML] Unravelling the actin cytoskeleton: a new competitive edge?
AJ Davidson, W Wood - Trends in Cell Biology, 2016 - cell.com
Dynamic rearrangements in the actin cytoskeleton underlie a wide range of cell behaviours,
which in turn contribute to many aspects of human health including embryogenesis, cancer …
which in turn contribute to many aspects of human health including embryogenesis, cancer …