The review begins with a concise description of the principles of phase separation. This is
followed by a comprehensive section on phase separation of chromatin, in which we recount …

Neurodevelopmental disorders (NDDs) and cancer share proteins, pathways, and
mutations. Their clinical symptoms are different. However, individuals with NDDs have …

In eukaryotes, higher-order chromatin organization is spatiotemporally regulated as
domains, for various cellular functions. However, their physical nature in living cells remains …

Dynamic chromatin behavior plays a critical role in various genome functions. However, it
remains unclear how chromatin behavior changes during interphase, where the nucleus …

Nuclear bodies are membraneless condensates that may form via liquid-liquid phase
separation. The viscoelastic chromatin network could impact their stability and may hold the …

Chemicals or drugs can accumulate within biomolecular condensates formed through phase
separation in cells. Here, we use super-resolution imaging to search for chemicals that …

Many membraneless organelles, or biological condensates, form through phase separation,
and play key roles in signal sensing and transcriptional regulation. While the functional …

The genetic material of eukaryotes is segregated into transcriptionally active euchromatin
and silent heterochromatin compartments. The spatial arrangement of chromatin …

After 60 years of chromatin investigation, our understanding of chromatin organization has
evolved from static chromatin fibers to dynamic nuclear compartmentalization. Chromatin is …

Eukaryotic genome DNA is wrapped around core histones and forms a nucleosome
structure. Together with associated proteins and RNAs, these nucleosomes are organized …