Macrophages are critical regulators of tissue homeostasis but are also abundant in the
tumor microenvironment (TME). In both primary tumors and metastases, such tumor …

Different stimuli can polarize macrophages into two basic types, M1 and M2. Tumor-
associated macrophages (TAMs) in the tumor microenvironment (TME) are composed of …

Non-small cell lung cancer (NSCLC) is the leading cause of death by cancer worldwide.
Despite developments in therapeutic approaches for the past few decades, the 5-year …

Cancer immunotherapy has significantly flourished and revolutionized the limited
conventional tumor therapies, on account of its good safety and long-term memory ability …

Tumor-associated macrophages (TAMs) are abundant, nearly accounting for 30–50% of
stromal cells in the tumor microenvironment. TAMs exhibit an immunosuppressive M2-like …

The paradigm for macrophage characterization has evolved from the simple M1/M2
dichotomy to a more complex model that encompasses the broad spectrum of macrophage …

Tumour-Associated Macrophages (TAMs) are one of the pivotal components of the tumour
microenvironment. Their roles in the cancer immunity are complicated, both pro-tumour and …

Sonodynamic therapy (SDT) has emerged as a highly effective modality for the treatment of
malignant tumors owing to its powerful penetration ability, noninvasiveness, site‐confined …

Immunotherapies have shown high clinical success, however, the therapeutical efficacy is
largely restrained by insufficient immune activation and an immunosuppressive …

Background The immunosuppressive microenvironment of lung cancer serves as an
important endogenous contributor to treatment failure. The present study aimed to …