[HTML][HTML] Glial cells and their function in the adult brain: a journey through the history of their ablation
S Jäkel, L Dimou - Frontiers in cellular neuroscience, 2017 - frontiersin.org
Glial cells, consisting of microglia, astrocytes and oligodendrocyte lineage cells as their
major components, constitute a large fraction of the mammalian brain. Originally considered …
major components, constitute a large fraction of the mammalian brain. Originally considered …
Cation-chloride cotransporters in neuronal development, plasticity and disease
Electrical activity in neurons requires a seamless functional coupling between
plasmalemmal ion channels and ion transporters. Although ion channels have been studied …
plasmalemmal ion channels and ion transporters. Although ion channels have been studied …
GABAA receptor trafficking-mediated plasticity of inhibitory synapses
B Luscher, T Fuchs, CL Kilpatrick - Neuron, 2011 - cell.com
Proper developmental, neural cell-type-specific, and activity-dependent regulation of
GABAergic transmission is essential for virtually all aspects of CNS function. The number of …
GABAergic transmission is essential for virtually all aspects of CNS function. The number of …
KCC2 rescues functional deficits in human neurons derived from patients with Rett syndrome
Rett syndrome is a severe form of autism spectrum disorder, mainly caused by mutations of
a single gene methyl CpG binding protein 2 (MeCP2) on the X chromosome. Patients with …
a single gene methyl CpG binding protein 2 (MeCP2) on the X chromosome. Patients with …
NMDA receptor activity downregulates KCC2 resulting in depolarizing GABAA receptor–mediated currents
KCC2 is a neuron-specific K+-Cl− co-transporter that maintains a low intracellular Cl−
concentration that is essential for hyperpolarizing inhibition mediated by GABAA receptors …
concentration that is essential for hyperpolarizing inhibition mediated by GABAA receptors …
Depolarising and Hyperpolarising Actions of GABAA Receptor Activation on Gonadotrophin‐Releasing Hormone Neurones: Towards an Emerging Consensus
AE Herbison, SM Moenter - Journal of neuroendocrinology, 2011 - Wiley Online Library
The gonadotrophin‐releasing hormone (GnRH) neurones represent the final output
neurones of a complex neuronal network that controls fertility. It is now appreciated that …
neurones of a complex neuronal network that controls fertility. It is now appreciated that …
[HTML][HTML] Chloride transporters and GABA polarity in developmental, neurological and psychiatric conditions
JT Schulte, CJ Wierenga, H Bruining - Neuroscience & Biobehavioral …, 2018 - Elsevier
Neuronal chloride regulation is a determinant factor for the dynamic tuning of GABAergic
inhibition during and beyond brain development. This regulation is mainly dependent on the …
inhibition during and beyond brain development. This regulation is mainly dependent on the …
Current view on the functional regulation of the neuronal K+-Cl− cotransporter KCC2
I Medina, P Friedel, C Rivera, KT Kahle… - Frontiers in cellular …, 2014 - frontiersin.org
In the mammalian central nervous system (CNS), the inhibitory strength of chloride (Cl−)-
permeable GABAA and glycine receptors (GABAAR and GlyR) depends on the intracellular …
permeable GABAA and glycine receptors (GABAAR and GlyR) depends on the intracellular …
Pharmacological enhancement of KCC2 gene expression exerts therapeutic effects on human Rett syndrome neurons and Mecp2 mutant mice
Rett syndrome (RTT) is a neurodevelopmental disorder caused by mutations in the methyl
CpG binding protein 2 (MECP2) gene. There are currently no approved treatments for RTT …
CpG binding protein 2 (MECP2) gene. There are currently no approved treatments for RTT …
Alterations in GABAA-Receptor Trafficking and Synaptic Dysfunction in Brain Disorders
GABAA receptors (GABAAR) are the major players in fast inhibitory neurotransmission in the
central nervous system (CNS). Regulation of GABAAR trafficking and the control of their …
central nervous system (CNS). Regulation of GABAAR trafficking and the control of their …