Alternative splicing is a post-transcriptional regulatory mechanism producing distinct mRNA
molecules from a single pre-mRNA with a prominent role in the development and function of …

Fusion genes are key cancer driver genes that can be used as potential drug targets in
precision therapies, and they can also serve as accurate diagnostic and prognostic …

Fusion genes formed by chromosomal rearrangements are common drivers of cancer.
Recent innovations in the field of next‐generation sequencing (NGS) have seen a dynamic …

Segmental duplications or low copy repeats (LCRs) constitute duplicated regions
interspersed in the human genome, currently neglected in standard analyses due to their …

DNA paralogs that have a length of at least 1 kilobase (kb) and are duplicated with a
sequence identity of over 90% are classified as low copy repeats (LCRs) or segmental …

A molecular level perspective on how novel phenotypes evolve is contingent on our
understanding of how genomes evolve through time, and of particular interest is how novel …

Alternative splicing is a post-transcriptional regulatory mechanism producing multiple
distinct mRNA molecules from a single pre-mRNA. Alternative splicing has a prominent role …

Alternative splicing is a post-transcriptional mechanism that increases the diversity of
expressed transcripts and plays an important role in regulating gene expression in the …

The formation of new genes by combining parts of existing genes is an important
evolutionary process. Remodelled genes, which we call composites, have been investigated …

Alzheimer's disease (AD) is a devastating neurodegenerative disorder characterised by
progressive intracellular accumulation of hyperphosphorylated tau and extracellular …