Endogenous biological clocks, orchestrated by the suprachiasmatic nucleus, time the
circadian rhythms that synchronize physiological and behavioural functions in humans. The …

Disruptions of normal circadian rhythms and sleep cycles are consequences of aging and
can profoundly affect health. Accumulating evidence indicates that circadian and sleep …

Circadian rhythms are physiological and behavioural cycles generated by an endogenous
biological clock, the suprachiasmatic nucleus. The circadian system influences the majority …

Neurodegenerative diseases encompass a large group of conditions that are clinically and
pathologically diverse yet are linked by a shared pathology of misfolded proteins. The …

Neurons in the suprachiasmatic nucleus (SCN) function as part of a central timing circuit that
drives daily changes in our behaviour and underlying physiology. A hallmark feature of SCN …

Since the identification of the causative gene in Huntington's disease (HD), a number of
animal models of this disorder have been developed. A frequently asked question is: which …

Disruptions in sleep/wake cycles, including decreased amplitude of rhythmic behaviors and
fragmentation of the sleep episodes, are commonly associated with aging in humans and …

The purpose of this study was to investigate the link between mutant huntingtin (Htt) and
neuronal damage in relation to mitochondria in Huntington's disease (HD). In an earlier …

There is increasing evidence of prodromal manifestation of neuropsychiatric symptoms in a
variety of neurodegenerative diseases such as Parkinson's disease (PD) and Huntington's …

Circadian rhythms align physiological functions with the light–dark cycle through oscillatory
changes in the abundance of proteins in the clock transcriptional programme. Timely …