[HTML][HTML] Brain-derived estrogen and neural function

DW Brann, Y Lu, J Wang, Q Zhang, R Thakkar… - Neuroscience & …, 2022 - Elsevier
Although classically known as an endocrine signal produced by the ovary, 17β-estradiol (E
2) is also a neurosteroid produced in neurons and astrocytes in the brain of many different …

[HTML][HTML] Sex differences in Parkinson's disease

GE Gillies, IS Pienaar, S Vohra, Z Qamhawi - Frontiers in …, 2014 - Elsevier
Parkinson's disease (PD) displays a greater prevalence and earlier age at onset in men.
This review addresses the concept that sex differences in PD are determined, largely, by …

Progestogens used in postmenopausal hormone therapy: differences in their pharmacological properties, intracellular actions, and clinical effects

FZ Stanczyk, JP Hapgood, S Winer… - Endocrine …, 2013 - academic.oup.com
The safety of progestogens as a class has come under increased scrutiny after the
publication of data from the Women's Health Initiative trial, particularly with respect to breast …

Neuron-derived estrogen regulates synaptic plasticity and memory

Y Lu, GR Sareddy, J Wang, R Wang, Y Li… - Journal of …, 2019 - Soc Neuroscience
17β-estradiol (E2) is produced from androgens via the action of the enzyme aromatase. E2
is known to be made in neurons in the brain, but its precise functions in the brain are …

Estrogen effects on the brain: actions beyond the hypothalamus via novel mechanisms.

BS McEwen, KT Akama, JL Spencer-Segal… - Behavioral …, 2012 - psycnet.apa.org
From its origins in how the brain controls the endocrine system via the hypothalamus and
pituitary gland, neuroendocrinology has evolved into a science that now includes hormone …

STRIPAK complexes: structure, biological function, and involvement in human diseases

J Hwang, DC Pallas - The international journal of biochemistry & cell …, 2014 - Elsevier
The mammalian striatin family consists of three proteins, striatin, S/G 2 nuclear autoantigen,
and zinedin. Striatin family members have no intrinsic catalytic activity, but rather function as …

Molecular mechanisms of steroid receptor-mediated actions by synthetic progestins used in HRT and contraception

D Africander, N Verhoog, JP Hapgood - Steroids, 2011 - Elsevier
Synthetic progestins are used by millions of women as contraceptives and in hormone
replacement therapy (HRT), although their molecular mechanisms of action are not well …

Estrogenic control of mitochondrial function and biogenesis

CM Klinge - Journal of cellular biochemistry, 2008 - Wiley Online Library
Estrogens have cell‐specific effects on a variety of physiological endpoints including
regulation of mitochondrial biogenesis and activity. Estrogens regulate gene transcription by …

International union of basic and clinical pharmacology. XCVII. G protein–coupled estrogen receptor and its pharmacologic modulators

ER Prossnitz, JB Arterburn, EH Ohlstein - Pharmacological reviews, 2015 - Elsevier
Estrogens are critical mediators of multiple and diverse physiologic effects throughout the
body in both sexes, including the reproductive, cardiovascular, endocrine, nervous, and …

Alzheimer's disease: review of hormone therapy trials and implications for treatment and prevention after menopause

VW Henderson - The Journal of steroid biochemistry and molecular …, 2014 - Elsevier
Hormonal changes associated with the menopausal transition and postmenopause have the
potential to influence processes linked to Alzheimer's disease symptoms and pathogenesis …