The recent maturation of single-cell RNA sequencing (scRNA-seq) technologies has
coincided with transformative new methods to profile genetic, epigenetic, spatial, proteomic …

The past decade has witnessed exponentially growing interest in the lateral habenula (LHb)
owing to new discoveries relating to its critical role in regulating negatively motivated …

Single-cell RNA sequencing (scRNA-seq) allows researchers to collect large catalogues
detailing the transcriptomes of individual cells. Unsupervised clustering is of central …

The human brain is subdivided into distinct anatomical structures, including the neocortex,
which in turn encompasses dozens of distinct specialized cortical areas. Early …

INTRODUCTION A mechanistic understanding of brain function requires the identification of
distinct cell types in the brain at a molecular, spatial, and functional level. The preoptic …

INTRODUCTION During embryogenesis, pluripotent cells gradually become specialized
and acquire distinct functions and morphologies. Because much of the specification process …

Amacrine cells (ACs) are a diverse class of interneurons that modulate input from
photoreceptors to retinal ganglion cells (RGCs), rendering each RGC type selectively …

The lineage relationships among the hundreds of cell types generated during development
are difficult to reconstruct. A recent method, GESTALT, used CRISPR–Cas9 barcode editing …

Neuronal types in the central nervous system differ dramatically in their resilience to injury or
other insults. Here we studied the selective resilience of mouse retinal ganglion cells …

High-acuity vision in primates, including humans, is mediated by a small central retinal
region called the fovea. As more accessible organisms lack a fovea, its specialized function …