Epidermal growth factor receptor (EGFR), the receptor for members of the epidermal growth
factor family, regulates cell proliferation and signal transduction; moreover, EGFR is related …

Morpholine, a six-membered heterocycle containing one nitrogen and one oxygen atom, is a
moiety of great significance. It forms an important intermediate in many industrial and …

Epidermal growth factor receptor (EGFR) is of great significance in mediating cell signaling
transduction and tumor behaviors. Currently, third-generation inhibitors of EGFR, especially …

The EGFR family play a significant role in cell signal transduction and their overexpression
is implicated in the pathogenesis of numerous human solid cancers. Inhibition of the EGFR …

The epidermal growth factor receptor (EGFR) plays a critical role in the tumorigenesis of
various forms of cancer. Targeting the mutant forms of EGFR has been identified as an …

Activation of the alternative pathways and abnormal signaling transduction are frequently
observed in third-generation EGFR-TKIs (epidermal growth factor receptor tyrosine kinase …

Overexpression of the epidermal growth factor receptor (EGFR) has been linked to several
human cancers, including esophageal cancer, pancreatic cancer, anal cancer, breast …

Polypharmacology has been increasingly advocated for the therapeutic intervention in
complex pathological conditions, exemplified by cancer. Although kinase inhibitors (KIs) …

Thirty-two novel urea/thiourea compounds as potential kinase inhibitor were designed,
synthesized and evaluated for their cytotoxic activity on breast (MCF7), colon (HCT116) and …

Substituted thiourea derivatives possess confirmed cytotoxic activity towards cancer but also
normal cells. To develop new selective antitumor agents, a series of 3-(trifluoromethyl) …