Depression's burden of disease goes beyond functioning and quality of life and extends to
somatic health. Results from longitudinal cohort studies converge in illustrating that major …

A plethora of research has implicated hundreds of putative biomarkers for depression, but
has not yet fully elucidated their roles in depressive illness or established what is abnormal …

A growing body of evidence supports an important role for alterations in the brain-gut-
microbiome axis in the aetiology of depression and other psychiatric disorders. The potential …

Objective: Major depressive disorder (MDD) is a severe mood disorder affecting individuals
of all ages and is characterised by single or recurrent major depressive episodes. Key …

Depression has been associated with inflammatory pathophysiological mechanisms,
including alterations in amount of circulating immune cells. However, no meta-analysis …

While researchers are struggling to develop a vaccine for coronavirus disease, it is important
to evolve effective therapeutic strategies to save lives. The majority of coronavirus disease …

Mood disorders such as depression are among the most prevalent psychiatric disorders in
the United States, but they are inadequately treated in a substantial proportion of patients …

Neurotransmitters and neurochemicals can act on lymphocytes by binding to receptors
expressed by lymphocytes. This review describes lymphocyte expression of receptors for a …

Abstract Background Major Depressive Disorder (MDD) is a severe psychiatric disorder
whose pathological mechanisms are largely unknown. In the field of immuno-psychiatry …

Given the role of low-grade inflammation in the pathophysiology of major depressive
disorder (MDD), anti-inflammatory strategies may improve treatment outcomes in some …