The spinocerebellar ataxias (SCAs) are a genetically heterogeneous group of autosomal
dominantly inherited progressive disorders, the clinical hallmark of which is loss of balance …

The spinocerebellar ataxias (SCAs) comprise more than 40 autosomal dominant
neurodegenerative disorders that present principally with progressive ataxia. Within the past …

Tandem repeat diseases include the neurodegenerative disorders known as polyglutamine
(polyQ) diseases, caused by CAG repeat expansions in the coding regions of the respective …

Objective Machado–Joseph disease (SCA3/MJD) is the most frequent spinocerebellar
ataxia worldwide and characterized by brainstem, basal ganglia, and cerebellar damage …

Background Given that new therapeutic options for spinocerebellar ataxias are on the
horizon, there is a need for markers that reflect disease‐related alterations, in particular, in …

The spinocerebellar ataxias (SCAs) are a group of dominantly inherited diseases that share
the defining feature of progressive cerebellar ataxia. The disease process, however, is not …

Spinocerebellar ataxia Type 3 (SCA3), the most common dominantly inherited ataxia, is a
polyglutamine neurodegenerative disease for which there is no disease-modifying therapy …

Objective As gene-based therapies may soon arise for patients with spinocerebellar ataxia
(SCA), there is a critical need to identify biomarkers of disease progression with effect sizes …

Ataxias, in particular if of genetic origin, have long been considered untreatable. They are
now becoming models for the development of targeted molecular therapies due to their …

The ability to image the whole brain through ever more subtle and specific
methods/contrasts has come to play a key role in understanding the basis of brain …