Combination therapies are superior to monotherapy for many cancers. This advantage was
historically ascribed to the ability of combinations to address tumor heterogeneity, but …

Mitogen-activated protein kinase (MAPK) pathways represent ubiquitous signal transduction
pathways that regulate all aspects of life and are frequently altered in disease. Here, we …

Modern medicine has been waging a war on cancer for nearly a century with no tangible
end in sight. Cancer treatments have significantly progressed, but the need to increase …

Summary Protein homeostasis, or" proteostasis," is indispensable for a balanced, healthy
environment within the cell. However, when natural proteostasis mechanisms are …

The increase in available high-throughput molecular data creates computational challenges
for the identification of cancer genes. Genetic as well as non-genetic causes contribute to …

Although cancer immunotherapy has taken center stage in mainstream oncology inducing
complete and long-lasting tumor regression, only a subset of patients receiving treatment …

Cancer arises from a multitude of disorders resulting in loss of differentiation and a stem cell-
like phenotype characterized by uncontrolled growth. Polycomb Group (PcG) proteins are …

During cancer evolution, constituent tumor cells compete under dynamic selection
pressures. Phenotypic variation can be observed as intratumor heterogeneity, which is …

Inherent or acquired resistance to sotorasib poses a substantialt challenge for NSCLC
treatment. Here, we demonstrate that acquired resistance to sotorasib in isogenic cells …

Simple Summary Our manuscript summarizes the up-to-date data on the complex and
dynamic nature of adaptation mechanisms and evolutionary processes taking place during …