Imidazoquinoline derivatives (IMDs) and related compounds function as synthetic agonists
of Toll-like receptors 7 and 8 (TLR7/8) and one is FDA approved for topical antiviral and skin …

Personalized cancer vaccines (PCVs) are reinvigorating vaccine strategies in cancer
immunotherapy. In contrast to adoptive T-cell therapy and checkpoint blockade, the PCV …

Abstract Toll-like receptor 9 (TLR9) is a pattern recognition receptor that is predominantly
located intracellularly in immune cells, including dendritic cells, macrophages, natural killer …

Protein–RNA interactions have crucial roles in various cellular activities, which, when
dysregulated, can lead to a range of human diseases. The identification of small molecules …

Recognition of invading pathogens by the innate immune system is essential to initiate
antimicrobial responses and trigger adaptive immunity. This is largely mediated by an array …

Toll-like receptors (TLRs) are key components of the innate immune system and serve as a
crucial link between innate and acquired immunity. In addition to immune function, TLRs are …

The discovery of the TLRs family and more precisely its functions opened a variety of gates
to modulate immunological host responses. TLRs 7/8 are located in the endosomal …

TLR7 and TLR8 are pattern recognition receptors that reside in the endosome and are
activated by ssRNA molecules. TLR7 and TLR8 are normally part of the antiviral defense …

Tumor-associated macrophages (TAMs) are often abundant in solid cancers, assuming an
immunosuppressive (M2-like) phenotype which supports tumor growth and immune escape …

A3 adenosine receptor (A3AR) positive allosteric modulators (PAMs)(2, 4-disubstituted-1 H-
imidazo [4, 5-c] quinolin-4-amines) allosterically increase the E max of A3AR agonists, but …