The ACC and the AHA have long been involved in the joint development of practice
guidelines designed to assist healthcare providers in the management of selected …

The ACC and the AHA have long been involved in the joint development of practice
guidelines designed to assist healthcare providers in the management of selected …

with the matrix and with the periodicity of negative charges on collagen. Crystals initially
form octacalcium phosphate [Ca8H2 (PO4) 6· 5H2O], which reorganizes and seeds epitaxial …

ACE has been identified in aortic sclerotic lesions. 13 Although there is evidence that some
ACE may be produced locally, the majority was extracellular and colocalized with …

Background—For nearly a century, the mechanical failure of calcified heart valves was
attributed to a passive degenerative process. Recently, several case reports described bone …

The study of the cellular and molecular pathogenesis of heart valve disease is an emerging
area of research made possible by the availability of cultures of valve interstitial cells (VICs) …

Background—Calcific aortic stenosis is the third most common cardiovascular disease in the
United States. We hypothesized that the mechanism for aortic valve calcification is similar to …

Background—The pathophysiology of aortic stenosis is incompletely understood, and the
relative contributions of valvular calcification and inflammation to disease progression are …

Calcific aortic valve stenosis (CAVS) is a major health problem facing aging societies. The
identification of osteoblast-like and osteoclast-like cells in human tissue has led to a major …

BACKGROUND: Aortic valve stenosis characteristically progresses due to cuspal
calcification, often necessitating valve replacement surgery. The present study investigated …