Prostate cancer (PCa) is the most common male malignancy and the fifth leading cause of
cancer death in men worldwide. Prostate cancer cells are characterized by a hybrid …

Lipid droplets are important for cancer cell growth and survival. However, the mechanism
underlying the initiation of lipid droplet lipolysis is not well understood. We demonstrate here …

Emerging evidence suggests that phosphoethanolamine/phosphocholine phosphatase 1
(PHOSPHO1), a specific phosphoethanolamine and phosphocholine phosphatase, is …

Aberrantly upregulated choline phospholipid metabolism is a novel emerging hallmark of
cancer, and choline kinase α (CHKα), a key enzyme for phosphatidylcholine production, is …

A special storage container called Mare Nectaris bears a close relationship with Feng-flavor
Baijiu quality during aging. The goal of this work is to unveil molecular mechanism of the …

Upregulated choline metabolism, characterized by an increase in phosphocholine (PCho),
is a hallmark of oncogenesis and tumor progression. Choline kinase (ChoK), the enzyme …

Choline kinase (ChoK) is a cytosolic enzyme that catalyzes the phosphorylation of choline to
form phosphorylcholine (P Cho) in the presence of ATP and magnesium. ChoK is required …

Background Diabetes mellitus type 2 (DM2) is a modifiable risk factor associated with
pancreatic carcinogenesis and tumor progression on the basis of epidemiology studies, but …

Aberrant choline metabolism, characterized by an increase in total choline-containing
compounds, phosphocholine and phosphatidylcholine (PC), is a metabolic hallmark of …

The short-chain dehydrogenase/reductase (SDR) superfamily has essential roles in lipid
metabolism and redox sensing. In recent years, accumulating evidence highlights the …