Obesity II: establishing causal links between chemical exposures and obesity

JJ Heindel, S Howard, K Agay-Shay, JP Arrebola… - Biochemical …, 2022 - Elsevier
Obesity is a multifactorial disease with both genetic and environmental components. The
prevailing view is that obesity results from an imbalance between energy intake and …

[HTML][HTML] A review of environmental metabolism disrupting chemicals and effect biomarkers associating disease risks: Where exposomics meets metabolomics

J Sun, R Fang, H Wang, DX Xu, J Yang, X Huang… - Environment …, 2022 - Elsevier
Humans are exposed to an ever-increasing number of environmental toxicants, some of
which have gradually been elucidated to be important risk factors for metabolic diseases …

[HTML][HTML] The relationship between phthalates and diabetes: a review

M Mariana, E Cairrao - Metabolites, 2023 - mdpi.com
Since the beginning of their production, in the 1930s, phthalates have been widely used in
the plastics industry to provide durability and elasticity to polymers that would otherwise be …

Lycopene prevents DEHP-induced liver lipid metabolism disorder by inhibiting the HIF-1α-induced PPARα/PPARγ/FXR/LXR system

Y Zhao, DX Ma, HG Wang, MZ Li… - Journal of Agricultural …, 2020 - ACS Publications
Di (2-ethylhexyl) phthalate (DEHP) is a widespread pollutant that badly affects animals and
human health. Lycopene (LYC) has been used as a dietary supplement that has effective …

Di (2-ethylhexyl) phthalate disturbs cholesterol metabolism through oxidative stress in rat liver

G Li, CY Zhao, Q Wu, Z Kang, JT Zhang… - Environmental …, 2022 - Elsevier
Abstract Di (2-ethylhexyl) phthalate (DEHP) is widely used and has been implicated in
hepatotoxicity, although the mechanism is unclear. Here, we investigated the effect of DEHP …

Probiotic reduced the impact of phthalates and bisphenol A mixture on type 2 diabetes mellitus development: Merging bioinformatics with in vivo analysis

K Baralić, K Živančević, D Jorgovanović… - food and chemical …, 2021 - Elsevier
Abstract Linkage between bis (2-ethylhexyl) phthalate (DEHP), dibutyl phthalate (DBP), and
bisphenol A (BPA) co-exposure and type 2 diabetes mellitus (T2DM), as well as ability of …

Mono-2-ethylhexyl phthalate (MEHP) promoted lipid accumulation via JAK2/STAT5 and aggravated oxidative stress in BRL-3A cells

Y Zhang, S Wang, T Zhao, L Yang, S Guo, Y Shi… - Ecotoxicology and …, 2019 - Elsevier
Abstract Mono-2-ethylhexyl phthalate (MEHP), as the major metabolite of Di-(2-ethylhexyl)
phthalate (DEHP), can induce lipid accumulation in hepatocytes and further leads to non …

[HTML][HTML] Assessment of exposure to di-(2-ethylhexyl) phthalate (DEHP) metabolites and bisphenol A (BPA) and its importance for the prevention of cardiometabolic …

F Carli, D Ciociaro, A Gastaldelli - Metabolites, 2022 - mdpi.com
Exposomics analyses have highlighted the importance of biomonitoring of human exposure
to pollutants, even non-persistent, for the prevention of non-communicable diseases such as …

[HTML][HTML] Prenatal exposure to low-dose di-(2-ethylhexyl) phthalate (DEHP) induces potentially hepatic lipid accumulation and fibrotic changes in rat offspring

HY Su, CS Lai, KH Lee, YW Chiang, CC Chen… - Ecotoxicology and …, 2024 - Elsevier
Abstract Di (2-ethylhexyl) phthalate (DEHP) is a plasticizer that is widely used to enhance
the flexibility and durability of various products. As an endocrine disruptor, DEHP can …

[HTML][HTML] Resveratrol Butyrate Ester Supplementation Blunts the Development of Offspring Hypertension in a Maternal Di-2-ethylhexyl Phthalate Exposure Rat Model

YL Tain, CY Hou, GP Chang-Chien, S Lin, CN Hsu - Nutrients, 2023 - mdpi.com
Resveratrol (REV) is a plant polyphenol with a plethora of beneficial properties. We
previously enhanced the efficacy of REV via esterification of REV with butyrate to form …