The sodium iodide symporter (NIS) is an intrinsic plasma membrane protein that mediates
active iodide transport into the thyroid gland and into several extrathyroidal tissues, in …

Preclinical and clinical tomographic imaging systems increasingly are being utilized for non-
invasive imaging of reporter gene products to reveal the distribution of molecular …

We recently demonstrated tumor-selective iodide uptake and therapeutic efficacy of
radioiodine in neuroblastoma tumors after systemic nonviral polyplex-mediated sodium …

The tumor-homing property of mesenchymal stem cells (MSCs) allows targeted delivery of
therapeutic genes into the tumor microenvironment. The application of sodium iodide …

Due to its dual role as reporter and therapy gene, the sodium iodide symporter (NIS) allows
noninvasive imaging of functional NIS expression by 123 I-scintigraphy or 124 I-PET …

Purpose The human sodium/iodide symporter (hNIS) is a well-established target in thyroid
disease and reporter gene imaging using gamma emitters 123 I-iodide, 131 I-iodide and …

The clinical application of positron-emission-tomography-based reporter gene imaging will
expand over the next several years. The translation of reporter gene imaging technology into …

We compare and contrast the development of optical molecular imaging techniques with
nuclear medicine with a didactic emphasis for initiating readers into the field of molecular …

Tumor responses to therapy in the clinic are still evaluated primarily from non-invasive
imaging measurements of reductions in tumor size. This approach, however, lacks sensitivity …

Radioiodines have a long history in nuclear medicine. Herein, we discuss the production,
properties and applications of these versatile iodine‐based imaging and theragnostic …