Global incidence and mortality of severe fungal disease

DW Denning - The Lancet Infectious Diseases, 2024 - thelancet.com
Current estimates of fungal disease incidence and mortality are imprecise. Population at risk
denominators were used to estimate annual incidence for 2019–21. Extensive literature …

Evolution of the human pathogenic lifestyle in fungi

A Rokas - Nature Microbiology, 2022 - nature.com
Fungal pathogens cause more than a billion human infections every year, resulting in more
than 1.6 million deaths annually. Understanding the natural history and evolutionary ecology …

Nanotechnology-based ocular drug delivery systems: recent advances and future prospects

S Li, L Chen, Y Fu - Journal of Nanobiotechnology, 2023 - Springer
Ocular drug delivery has constantly challenged ophthalmologists and drug delivery
scientists due to various anatomical and physiological barriers. Static and dynamic ocular …

Cell wall destruction and internal cascade synergistic antifungal strategy for fungal keratitis

Y Ye, J He, H Wang, W Li, Q Wang, C Luo, X Tang… - ACS …, 2022 - ACS Publications
Fungal keratitis is one of the most common blindness-causing diseases, but clinical
antifungal treatment remains a challenge. The fungal cell wall and biofilm matrix which …

Drug delivery to the anterior segment of the eye: A review of current and future treatment strategies

M Mofidfar, B Abdi, S Ahadian, E Mostafavi… - International journal of …, 2021 - Elsevier
Research in the development of ophthalmic drug formulations and innovative technologies
over the past few decades has been directed at improving the penetration of medications …

[HTML][HTML] The global epidemiology and clinical diagnosis of Acanthamoeba keratitis

Y Zhang, X Xu, Z Wei, K Cao, Z Zhang… - Journal of Infection and …, 2023 - Elsevier
Acanthamoeba keratitis is a rare parasitic infection of the cornea that can lead to permanent
blindness if not diagnosed and treated promptly. We collected data on the incidences of …

Visualized gallium/lyticase‐integrated antifungal strategy for fungal keratitis treatment

J He, Y Ye, D Zhang, K Yao, M Zhou - Advanced Materials, 2022 - Wiley Online Library
Fungal keratitis has been one of the common corneal infections that causes blindness, but
an effective antifungal strategy remains a challenge. The exopolysaccharides both in the …

[HTML][HTML] Mycotic keratitis—a global threat from the filamentous fungi

JJ Hoffman, MJ Burton, A Leck - Journal of Fungi, 2021 - mdpi.com
Mycotic or fungal keratitis (FK) is a sight-threatening disease, caused by infection of the
cornea by filamentous fungi or yeasts. In tropical, low and middle-income countries, it …

A host defense peptide mimetic, brilacidin, potentiates caspofungin antifungal activity against human pathogenic fungi

TF Dos Reis, PA De Castro, RW Bastos… - Nature …, 2023 - nature.com
Fungal infections cause more than 1.5 million deaths a year. Due to emerging antifungal
drug resistance, novel strategies are urgently needed to combat life-threatening fungal …

PANoptosis: Mechanisms, biology, and role in disease

X Sun, Y Yang, X Meng, J Li, X Liu… - Immunological …, 2024 - Wiley Online Library
Cell death can be executed through distinct subroutines. PANoptosis is a unique
inflammatory cell death modality involving the interactions between pyroptosis, apoptosis …