Oxidative stress has been considered as a major hallmark for the pathogenesis and
development of type 2 diabetes mellitus (T2DM), but still it is debatable whether it is a mere …

In both type 1 and type 2 diabetes, the late diabetic complications in nerve, vascular
endothelium, and kidney arise from chronic elevations of glucose and possibly other …

In both type 1 and type 2 diabetes, diabetic complications in target organs arise from chronic
elevations of glucose. The pathogenic effect of high glucose, possibly in concert with fatty …

The relentless decline in β-cell function frequently observed in type 2 diabetic patients,
despite optimal drug management, has variously been attributed to glucose toxicity and …

Glucotoxicity, lipotoxicity, and glucolipotoxicity are secondary phenomena that are proposed
to play a role in all forms of type 2 diabetes. The underlying concept is that once the primary …

Glucose in chronic excess causes toxic effects on structure and function of organs, including
the pancreatic islet. Multiple biochemical pathways and mechanisms of action for glucose …

Chronic exposure to hyperglycemia can lead to cellular dysfunction that may become
irreversible over time, a process that is termed glucose toxicity. Our perspective about …

Diabetes mellitus type 1 and 2 (T1DM and T2DM) are complex multifactorial diseases. Loss
of beta-cell function caused by reduced secretory capacity and enhanced apoptosis is a key …

Methods. BMI at date of transplant was calculated for all patients using BMI= body weight (in
kg)[geometrically equal to] stature (height, in meters) squared. BMI values were further …

Gene expression is modulated by both physiological signals (hormones, cytokines, etc.) and
environmental stimuli (physical parameters, xenobiotics, etc.). Oxidative stress appears to be …