Braak's hypothesis has been extremely influential over the last two decades. However,
neuropathological and clinical evidence suggest that the model does not conform to all …

Sleep disorders are among the most common non-motor manifestations in Parkinson's
disease (PD) and have a significant negative impact on quality of life. While sleep disorders …

Importance There is increasing evidence that Parkinson disease (PD) is heterogeneous in
its clinical presentation and prognosis. Defining subtypes of PD is needed to better …

Parkinson's disease (PD) is associated with excessive beta activity in the basal ganglia.
Brain sensing implants aim to leverage this biomarker for demand-dependent adaptive …

Objective Quantification of gait with wearable technology is promising; recent cross‐
sectional studies showed that gait characteristics are potential prodromal markers for …

Objective: We investigated an array of possible markers of early dementia in Parkinson
disease. Methods: We performed a comprehensive assessment of autonomic, sleep …

Increasing recognition that Parkinson's disease (PD) may start outside of the substantia
nigra has led to a rapidly expanding effort to define prodromal stages of PD, before motor …

Objective: Nonmotor symptoms (NMS) are common in patients with established Parkinson
disease (PD) but their frequency in early PD has not been extensively studied. Our aim was …

Sleep disorders (SDs) are common non-motor symptoms of Parkinson's disease (PD) with
wide variability in their prevalence rates. The etiology of SDs in PD is multifactorial because …

Objective To determine the pathologic substrates in patients with rapid eye movement
(REM) sleep behavior disorder (RBD) with or without a coexisting neurologic disorder …