γ-Aminobutyric acid type A receptors (GABAARs) are the main inhibitory mediators in the
central nervous system (CNS). GABAARs are pentameric ligand gated ion channels, and the …

Introduction: Lacosamide has been used in epilepsy patients in the United States, Europe
and Asia since it was approved by the FDA in 2008. Many patients have benefited from this …

Gangliogliomas (GGs) are low-grade brain tumours that cause intractable focal epilepsy in
children and adults. In GG, as in epileptogenic focal malformations (ie, tuberous sclerosis …

After 50 years, the heterologous expression of proteins in Xenopus laevis oocytes is still
essential in many research fields. New approaches and revised protocols, but also classical …

Mutations in SCN1A gene, encoding the voltage-gated sodium channel (VGSC) NaV1. 1,
are widely recognized as a leading cause of genetic febrile seizures (FS), due to the …

Epilepsy is one of the most common brain disorders, affecting more than 50 million people
worldwide. Although its treatment is currently symptomatic, the last generation of anti-seizure …

Introduction: Neurological diseases present a difficult challenge in drug discovery. Many of
the current treatments have limited efficiency or result in a variety of debilitating side effects …

El presente documento de consenso se ha desarrollado con el objetivo de optimizar el
tratamiento de pacientes con crisis epilépticas (CE) en los ámbitos de urgencias …

The lithium-pilocarpine model in rats is commonly used to study the characteristic events of
acute status epilepticus (SE), epileptogenesis and temporal lobe epilepsy (TLE). Here we …

Lennox-Gastaut syndrome (LGS) is a severe, chronic, complex form of early childhood-onset
epilepsy characterized by multiple seizure types, generalized slow (≤ 2.5 Hz) spike-and …