Abstract Calcium (Ca2+) signalling is of paramount importance to immunity. Regulated
increases in cytosolic and organellar Ca2+ concentrations in lymphocytes control complex …

Cancers are able to grow by subverting immune suppressive pathways, to prevent the
malignant cells as being recognized as dangerous or foreign. This mechanism prevents the …

Under physiological conditions, adenosine triphosphate (ATP) is present at low levels in the
extracellular milieu, being massively released by stressed or dying cells. Once outside the …

Purinergic signalling, ie, the role of nucleotides as extracellular signalling molecules, was
proposed in 1972. However, this concept was not well accepted until the early 1990's when …

Virtually, all tumor cells as well as all immune cells express plasma membrane receptors for
extracellular nucleosides (adenosine) and nucleotides (ATP, ADP, UTP, UDP and sugar …

The P2X7 receptor is a cation channel activated by high concentrations of adenosine
triphosphate (ATP). Upon long-term activation, it complexes with membrane proteins forming …

Seven P2X ion channel nucleotide receptor subtypes have been cloned and characterised.
P2X7 receptors (P2X7R) are unusual in that there are extra amino acids in the intracellular …

In the tumor microenvironment (TME) ATP and its receptor P2X7 exert a pivotal influence on
cancer growth and tumor–host interactions. Here we analyzed the different effect of P2X7 …

Damage-associated molecular patterns (DAMPs) are released in response to cell death and
stress, and are potent triggers of sterile inflammation. Recent evidence suggests that DAMPs …

Immune-mediated inflammatory diseases (IMIDs) encompass a wide range of seemingly
unrelated conditions, such as multiple sclerosis, rheumatoid arthritis, psoriasis, inflammatory …