Asymmetric dimethylarginine (ADMA) is an endogenous and competitive inhibitor of nitric
oxide synthase. Plasma levels of this inhibitor are elevated in patients with atherosclerosis …

This review summarizes the current status of protein arginine N-methylation reactions.
These covalent modifications of proteins are now recognized in a number of eukaryotic …

Endothelium plays a crucial role in the maintenance of vascular tone and structure.
Endothelial dysfunction is known to precede overt coronary artery disease. A number of …

Spinal muscular atrophy (SMA) is a common, often fatal, autosomal recessive disease
leading to progressive muscle wasting and paralysis as a result of degeneration of anterior …

Type I protein arginine methyltransferases catalyze the formation of asymmetric ω-NG, N G-
dimethylarginine residues by transferring methyl groups fromS-adenosyl-l-methionine to …

Asymmetrical dimethylarginine (ADMA) is an endogenous nitric oxide synthase inhibitor. It is
formed by protein arginine N-methyltransferases (PRMTs), which utilize S …

The guanidino-methylated arginine analogue NG monomethyl-l-arginine (l-NMMA) has
been the standard nitric oxide synthase inhibitor used to evaluate the role of the l-arginine …

The TIS21 immediate-early gene and leukemia-associated BTG1 gene encode proteins with
similar sequences. Two-hybrid analysis identified a protein that interacts with TIS21 and …

An increasing number of reports in the literature indicate that endogenously produced
inhibitors of nitric oxide synthase (NOS), particularly asymmetric dimethylarginine (ADMA) …

Arginine residues in RG-rich proteins are frequently dimethylated posttranslationally by
protein arginine methyltransferases (PRMTs). The most common methylation pattern is …