Connectome-based modelling of neurodegenerative diseases: towards precision medicine and mechanistic insight
JW Vogel, N Corriveau-Lecavalier… - Nature Reviews …, 2023 - nature.com
Neurodegenerative diseases are the most common cause of dementia. Although their
underlying molecular pathologies have been identified, there is substantial heterogeneity in …
underlying molecular pathologies have been identified, there is substantial heterogeneity in …
Initiation and progression of α-synuclein pathology in Parkinson's disease
GK Tofaris - Cellular and molecular life sciences, 2022 - Springer
Abstract α-Synuclein aggregation is a critical molecular process that underpins the
pathogenesis of Parkinson's disease. Aggregates may originate at synaptic terminals as a …
pathogenesis of Parkinson's disease. Aggregates may originate at synaptic terminals as a …
[HTML][HTML] Toward best practices for imaging transcriptomics of the human brain
Modern brainwide transcriptional atlases provide unprecedented opportunities for
investigating the molecular correlates of brain organization, as quantified using noninvasive …
investigating the molecular correlates of brain organization, as quantified using noninvasive …
[HTML][HTML] Imaging transcriptomics of brain disorders
Noninvasive neuroimaging is a powerful tool for quantifying diverse aspects of brain
structure and function in vivo, and it has been used extensively to map the neural changes …
structure and function in vivo, and it has been used extensively to map the neural changes …
Statistical testing in transcriptomic‐neuroimaging studies: A how‐to and evaluation of methods assessing spatial and gene specificity
Multiscale integration of gene transcriptomic and neuroimaging data is becoming a widely
used approach for exploring the molecular underpinnings of large‐scale brain organization …
used approach for exploring the molecular underpinnings of large‐scale brain organization …
Activated microglia facilitate the transmission of α-synuclein in Parkinson's disease
T Zheng, Z Zhang - Neurochemistry international, 2021 - Elsevier
Parkinson's disease (PD) is characterized by the loss of dopaminergic neurons in the
substantia nigra pars compacta and abnormal aggregates of α-synuclein protein called …
substantia nigra pars compacta and abnormal aggregates of α-synuclein protein called …
Differences in network controllability and regional gene expression underlie hallucinations in Parkinson's disease
A Zarkali, P McColgan, M Ryten, R Reynolds… - Brain, 2020 - academic.oup.com
Visual hallucinations are common in Parkinson's disease and are associated with poorer
prognosis. Imaging studies show white matter loss and functional connectivity changes with …
prognosis. Imaging studies show white matter loss and functional connectivity changes with …
[HTML][HTML] Spatial transcriptomic patterns underlying amyloid-β and tau pathology are associated with cognitive dysfunction in Alzheimer's disease
Amyloid-β (Aβ) and tau proteins accumulate within distinct neuronal systems in Alzheimer's
disease (AD). Although it is not clear why certain brain regions are more vulnerable to Aβ …
disease (AD). Although it is not clear why certain brain regions are more vulnerable to Aβ …
Multimodal phenotypic axes of Parkinson's disease
Individuals with Parkinson's disease present with a complex clinical phenotype,
encompassing sleep, motor, cognitive, and affective disturbances. However …
encompassing sleep, motor, cognitive, and affective disturbances. However …
Integrated transcriptomic and neuroimaging brain model decodes biological mechanisms in aging and Alzheimer's disease
Both healthy aging and Alzheimer's disease (AD) are characterized by concurrent
alterations in several biological factors. However, generative brain models of aging and AD …
alterations in several biological factors. However, generative brain models of aging and AD …