In recent years, there has been a surge of interest in using machine learning algorithms
(MLAs) in oncology, particularly for biomedical applications such as drug discovery, drug …

Hypervirulent Klebsiella pneumoniae causes liver abscess and potentially devastating
metastatic complications. The majority of Klebsiella-induced liver abscess are caused by the …

We report for the first time the use of experimental electron density (ED) as training data for
the generation of drug-like three-dimensional molecules based on the structure of a target …

As words can have multiple meanings that depend on sentence context, genes can have
various functions that depend on the surrounding biological system. This pleiotropic nature …

One of the key points of machine learning-assisted directed evolution (MLDE) is the
accurate learning of the fitness landscape, a conceptual mapping from sequence variants to …

RNA-binding proteins (RBPs) control RNA metabolism to orchestrate gene expression and,
when dysfunctional, underlie human diseases. Proteome-wide discovery efforts predict …

Similar to plant pathogens, phloem-feeding insects such as aphids deliver effector proteins
inside their hosts that act to promote host susceptibility and enable feeding and infestation …

Comprehensive protein function annotation is essential for understanding microbiome-
related disease mechanisms in the host organisms. However, a large portion of human gut …

Two recent studies exploited ultra-fast structural aligners and deep-learning approaches to
cluster the protein structure space in the AlphaFold Database. Barrio-Hernandez et al. 1 and …

Since the first report in 2009, at least ten additional viruses have been identified and
assigned to the proposed virus family Alternaviridae. Here we report two new mycoviruses …