Drug addiction may be a goal-directed choice driven by excessive drug value in negative
affective states, a habit driven by strong stimulus− response associations, or a compulsion …

Midbrain dopamine (DA) neurons are proposed to signal reward prediction error (RPE), a
fundamental parameter in associative learning models. This RPE hypothesis provides a …

Sophisticated behavioral paradigms partnered with the emergence of increasingly selective
techniques to target the basolateral amygdala (BLA) have resulted in an enhanced …

Introduction Debate continues over the precise causal contribution made by mesolimbic
dopamine systems to reward. There are three competing explanatory categories:'liking' …

In our target article, we proposed that addiction could be envisioned as misperformance of a
decision-making machinery described by two systems (deliberative and habit systems) …

The authors explore the division of labor between the basal ganglia-dopamine (BG-DA)
system and the orbitofrontal cortex (OFC) in decision making. They show that a primitive …

In this review we discuss the evidence that drug addiction, defined as a maladaptive
compulsive habit, results from the progressive subversion by addictive drugs of striatum …

The orbitofrontal cortex, as a part of prefrontal cortex, is implicated in executive function.
However, within this broad region, the orbitofrontal cortex is distinguished by its unique …

Background Our ability to measure the cognitive components of complex decision-making
across species has greatly facilitated our understanding of its neurobiological mechanisms …

Cocaine addiction is a major public health problem that is particularly difficult to treat.
Without medically proven pharmacological treatments, interventions to change the …